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Structured alcohol cessation support program versus current practice in acute alcoholic pancreatitis (PANDA): Study
Noor J Sissingh1, Anne Nagelhout2, Marc G Besselink3
1Department of Gastroenterology and Hepatology, Leiden University Medical Centre, Leiden, the Netherlands; Department of Research and Development, St. Antonius Hospital, Nieuwegein, the Netherlands.
A structured alcohol cessation support program may prevent recurrent acute pancreatitis after a first episode. The PANDA trial compares this program against current practices in a nationwide study.
Area of Science:
- Gastroenterology
- Addiction Medicine
- Clinical Trials
Background:
- Alcohol consumption is a primary risk factor for recurrent acute pancreatitis.
- Current clinical guidelines lack specific recommendations for alcohol cessation strategies.
- The PANDA trial addresses the need for evidence-based interventions to prevent pancreatitis recurrence.
Purpose of the Study:
- To investigate the efficacy of a structured alcohol cessation support program in preventing recurrent acute pancreatitis.
- To compare the outcomes of the intervention program versus standard care in patients with a first episode of acute alcoholic pancreatitis.
Main Methods:
- Nationwide cluster randomized superiority trial (PANDA trial).
- Hospitals randomized to either structured alcohol cessation support or current practice.
- Inclusion criteria: first episode of acute pancreatitis due to harmful drinking (AUDIT score specific ranges).
- Primary endpoint: recurrence of acute pancreatitis within one year.
- Secondary endpoints: alcohol use cessation/reduction, alcohol-related diseases, mortality, quality of life, QALYs, and costs.
Main Results:
- This section is not available in the provided abstract.
Conclusions:
- This is the first multicenter trial using a cluster randomized design to evaluate structured alcohol cessation support for preventing recurrent acute pancreatitis.
- The study aims to provide evidence for a new treatment strategy in managing patients with acute alcoholic pancreatitis.
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