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Identifying Coronary Artery Calcification on Non-gated Computed Tomography Scans
Published on: August 28, 2018
Coronary Artery Calcium Identified on Non-Gated Chest CT Scans: A Wasted Opportunity for Preventive Cardiological
Beatriz Valente Silva1, Miguel Nobre Menezes1, Rui Plácido1
1Cardiology Department, Centro Hospitalar Universitário Lisboa Norte, CAML, CCUL, Faculdade de Medicina, Universidade de Lisboa, Lisboa, Portugal.
Insights
Coronary artery calcium (CAC) on standard chest CT predicts cardiovascular events and mortality. Early detection of CAC on chest CT aids risk stratification, but underreporting is common.
Area of Science:
- Cardiovascular Imaging
- Radiology
- Preventive Cardiology
Background:
- Coronary artery calcium (CAC) on cardiac CT predicts cardiovascular events.
- Standard chest CT may detect CAC, offering a potential screening opportunity.
Purpose of the Study:
- Evaluate CAC on non-gated chest CT against coronary angiography (CAG).
- Assess CAC's impact on cardiovascular outcomes and mortality.
Main Methods:
- Retrospective analysis of 114 patients with prior chest CT and CAG.
- Quantitative (Agatston score) and qualitative CAC assessment on non-gated chest CT.
Main Results:
- Moderate/severe CAC on chest CT predicted significant coronary lesions (OR 22) and mortality (OR 4).
- Quantitative CAC predicted significant lesions (AUC 0.81).
- Significant CAC detected in 80% of chest CTs, but only 25% were reported.
Conclusions:
- CAC assessment on chest CT is feasible and correlates with coronary disease severity and mortality.
- Chest CT offers a chance for cardiovascular risk stratification, though underreporting is prevalent.
Background:
Coronary artery calcium (CAC) evaluated on dedicated cardiac computed tomography (CT) is an independent predictor of cardiovascular events. This study aimed to evaluate the correlation between CAC detected on non-gated standard chest CT and coronary lesions on coronary angiography (CAG) and determine its impact on prognosis.
Methods:
Consecutive patients who underwent CAG due to acute coronary syndrome and had prior non-contrasted non-gated chest CT were included and retrospectively evaluated. Coronary artery calcium was evaluated by quantitative (Agatston score) and qualitative (visual assessment) assessment.
Results:
A total of 114 patients were included in this study. The mean time difference between chest CT and CAG was 23 months. Coronary artery calcium was visually classified as mild, moderate, and severe in 31%, 33%, and 16% of patients, respectively. Moderate or severe CAC was an independent predictor of significant lesions on CAG (OR 22; 95% CI 8-61; p<0.001) and all-cause mortality (OR 4; 95% CI 2-9; p=0.001). Quantitative CAC evaluation accurately predicted significant lesions on CAG (AUC 0.81; p<0.001). While significant CAC was identified in 80% of chest CTs, formal reporting was 25%.
Conclusion:
Coronary artery calcium evaluation with chest CT was feasible and strongly associated with severity of coronary disease on CAG and mortality. Although the identification of CAC on chest CT represents a unique opportunity for cardiovascular risk stratification for preventive care, CAC underreporting is frequent.
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