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Related Experiment Videos

Excretory urography with iohexol: evaluation in children.

H L Magill, E A Clarke, S J Fitch

    Radiology
    |December 1, 1986
    PubMed
    Summary

    Iohexol, a nonionic contrast medium, is safe and effective for pediatric excretory urography. Doses above 300 mgI/kg ensure diagnostic quality, with iohexol showing superior visualization of collecting systems compared to iothalamate meglumine.

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    Area of Science:

    • Pediatric Radiology
    • Diagnostic Imaging
    • Contrast Media

    Background:

    • Excretory urography is crucial for evaluating pediatric renal and collecting systems.
    • Nonionic, low-osmolar contrast agents are preferred to minimize adverse reactions in children.
    • Iohexol is a second-generation nonionic contrast medium.

    Purpose of the Study:

    • To evaluate the safety and efficacy of iohexol for pediatric excretory urography.
    • To determine the minimum effective dose of iohexol for diagnostic imaging.
    • To compare the visualization quality of iohexol with iothalamate meglumine.

    Main Methods:

    • Multicenter clinical study involving 130 children undergoing excretory urography with iohexol.
    • Dose-ranging evaluation (150–660 mgI/kg) to establish minimum effective dose.

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  • Blinded comparison of 65 iohexol urograms with 65 iothalamate meglumine urograms.

    • Main Results:

    • Iohexol was well-tolerated with no significant adverse reactions.
    • Doses >300 mgI/kg consistently yielded diagnostic quality urograms.
    • Iohexol demonstrated statistically significant superior visualization of calyces and pelvoinfundibular structures compared to iothalamate meglumine.

    Conclusions:

    • Iohexol is a safe and effective contrast agent for pediatric excretory urography.
    • A minimum dose of 300 mgI/kg iohexol is recommended for diagnostic quality.
    • Iohexol offers advantages over iothalamate meglumine for visualizing the collecting system in children.