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Outcomes of transcatheter aortic valve replacement in patients with mitral annular calcification and concomitant

Soban Ahmad1, Amman Yousaf2, Ghulam Mujtaba Ghumman3

  • 1Division of Cardiovascular Medicine, University of Nebraska Medical Center, Omaha, NE, USA; Department of Medicine, East Carolina University, Greenville, NC, USA.

Cardiovascular Revascularization Medicine : Including Molecular Interventions
|October 22, 2023
PubMed

Insights

Transcatheter aortic valve replacement (TAVR) is safe for patients with non-severe mitral annular calcification (MAC). However, severe MAC increases bleeding risk, and MAC with mitral valve dysfunction (MVD) elevates mortality in TAVR patients.

Area of Science:

  • Cardiovascular Medicine
  • Interventional Cardiology
  • Valvular Heart Disease

Background:

  • Calcific aortic stenosis is a primary indication for transcatheter aortic valve replacement (TAVR).
  • Comorbid mitral annular calcification (MAC) frequently coexists in TAVR patients, with limited data on its impact.
  • The influence of MAC and concurrent mitral valve dysfunction (MVD) on TAVR outcomes requires further investigation.

Conclusions:

  • TAVR is generally safe for patients with non-severe MAC.
  • Severe MAC is associated with an increased risk of major bleeding post-TAVR.
  • Concomitant MVD in patients with MAC undergoing TAVR significantly increases mortality risk.
Abstract

Keywords:
Major bleedingMeta-analysisMitral annular calcification (MAC)Mitral regurgitationMitral stenosisMortalityTranscatheter aortic valve replacement (TAVR)

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