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Preparation of Stable Bicyclic Aziridinium Ions and Their Ring-Opening for the Synthesis of Azaheterocycles
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Piperidine: A Versatile Heterocyclic Ring for Developing Monoamine Oxidase Inhibitors
Jayalakshmi Jayan1, Namitha Chandran1, Amrutha Chandran Thekkantavida1
1Department of Pharmaceutical Chemistry, Amrita School of Pharmacy, Amrita Vishwa Vidyapeetham, AIMS Health Sciences Campus, Kochi, Kerala 682 041 India.
ACS Omega
|October 23, 2023
Summary
Piperine, a compound from black pepper, shows potential as a monoamine oxidase (MAO) inhibitor for neurodegenerative diseases. Research explores piperidine derivatives for safer, more effective MAO inhibition therapies.
Area of Science:
- Biochemistry
- Neuroscience
- Pharmacology
Background:
- Monoamine oxidase (MAO) enzymes catalyze neurotransmitter deamination and are implicated in neurodegeneration.
- Current MAO inhibitors for neurodegenerative diseases have significant side effects.
- Novel therapeutic strategies focus on selective and reversible MAO inhibition.
Purpose of the Study:
- To review structural modifications and structure-activity relationships of piperidine derivatives as MAO inhibitors.
- To explore piperine and its derivatives as potential therapeutic agents for neurodegenerative disorders.
- To identify novel compounds with improved MAO inhibitory profiles.
Main Methods:
- Literature review of studies on piperidine derivatives as MAO inhibitors.
- Analysis of structure-activity relationships for MAO inhibition.
- Focus on piperine as a lead compound.
Main Results:
- Piperine, a natural phytochemical, is a potent MAO inhibitor.
- Piperidine derivatives exhibit diverse pharmacological properties, including MAO inhibition.
- Structural modifications can enhance selectivity and reversibility of MAO inhibition.
Conclusions:
- Piperidine derivatives, particularly those inspired by piperine, represent a promising class of compounds for developing novel MAO inhibitors.
- Further research into structure-activity relationships can lead to safer and more effective treatments for neurodegenerative diseases.
- Targeting MAO with selective inhibitors offers a viable therapeutic avenue.
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