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Related Experiment Video

Updated: Jul 12, 2025

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Feasibility study on evaluating right ventricular diastolic function by new Tei'-Index.

Yicen Zhang1, Guotong Sun2,3, Wenyuan Zhu2

  • 1Department of Cardiology, Qingdao Municipal Hospital, University of Health and Rehabilitation Sciences, Qingdao, 266071, China.

Heliyon
|October 23, 2023
PubMed
Summary
This summary is machine-generated.

A new Tei'-index effectively evaluates right ventricular diastolic dysfunction. This index, unlike the standard Tei-index, shows significant changes in patients with isolated diastolic dysfunction, aiding in early detection.

Keywords:
EchocardiographyIsolated diastolic dysfunctionMyocardial performance index (Tei-index)Right ventricular function

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Area of Science:

  • Cardiology
  • Echocardiography
  • Diastology

Background:

  • The myocardial performance index (Tei) is used for right ventricular (RV) function assessment, but its utility in isolated diastolic dysfunction (IDD) is limited.
  • Evaluating RV diastolic function, particularly in early stages, requires sensitive and specific noninvasive markers.

Purpose of the Study:

  • To develop and validate a novel Tei'-index for assessing isolated diastolic dysfunction (IDD) of the right ventricle.
  • To determine if the new Tei'-index is more sensitive than the conventional Tei-index in detecting early RV diastolic dysfunction.

Main Methods:

  • Compared Tei and Tei' indices, including isovolumetric relaxation time (IRT), isovolumetric contraction time (ICT), ejection time (ET), and RV rapid filling time (RFT), in 21 patients with impaired RV relaxation and 44 controls.
  • Measured Doppler-derived parameters from RV outflow and tricuspid inflow velocity profiles.

Main Results:

  • The conventional Tei-index showed no significant difference between groups (0.21 ± 0.08 vs. 0.23 ± 0.07, PNS).
  • The novel Tei'-index was significantly shortened in the IDD group (0.24 ± 0.09 vs. 0.32 ± 0.12, p<0.05), attributed to prolonged IRT and RFT, and abbreviated ICT.
  • A Tei'-index cutoff of ≥0.31 identified impaired RV relaxation with 50% sensitivity and 86% specificity, correlating well with other diastolic parameters (E/A, E/e', DT).

Conclusions:

  • The new Tei'-index is highly effective and specific for evaluating early right ventricular diastolic dysfunction.
  • The Tei'-index can serve as a valuable noninvasive indicator for detecting isolated diastolic dysfunction (IDD) in clinical practice.