IL-10 (-1082 G/A) polymorphism in Bataknese with schizophrenia
Sarah A Mardhiyah1, Elmeida Effendy2, Nazli M Nasution2
1Psychiatry Residency Program, Faculty of Medicine, Universitas Sumatera Utara, Indonesia.
Journal of Taibah University Medical Sciences
|October 23, 2023
Summary
The interleukin-10 (IL-10) gene A allele and AA genotype at -1082 G/A are risk factors for schizophrenia in the Indonesian Bataknese population. This finding highlights the role of IL-10 gene polymorphisms in schizophrenia susceptibility.
Area of Science:
- Genetics
- Psychiatry
- Molecular Biology
Background:
- Interleukin-10 (IL-10) gene promoter polymorphisms are linked to schizophrenia susceptibility.
- Previous studies suggest associations between IL-10 gene variations and schizophrenia risk.
Purpose of the Study:
- To investigate the association between the IL-10 (-1082 G/A) gene polymorphism and schizophrenia in the Bataknese population of Indonesia.
- To determine if specific IL-10 genotypes or alleles increase schizophrenia risk within this ethnic group.
Main Methods:
- A case-control study involving 194 unrelated participants (97 cases, 97 controls) from the Bataknese tribe.
- Polymerase chain reaction restriction fragment length polymorphism (PCR-RFLP) was used for molecular genotyping to analyze IL-10 (-1082 G/A) genotype and allele distribution.
Main Results:
- Allele A was dominant in the Bataknese tribe.
- Homozygous GG genotypes were absent in both case and control groups.
- The A allele (OR=2.26) and AA genotype (OR=2.56) were identified as significant risk factors for schizophrenia.
Conclusions:
- The IL-10 gene polymorphism at -1082 G/A, specifically the A allele and AA genotype, contributes to schizophrenia susceptibility in the Bataknese population.
- These findings underscore the importance of specific IL-10 genetic variations in the etiology of schizophrenia within this Indonesian ethnic group.
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