Related Experiment Video

Updated: Jul 12, 2025

Immunometabolic Circuits in Infection for Advancing Host Directed Therapies
11:12

Immunometabolic Circuits in Infection for Advancing Host Directed Therapies

Published on: September 13, 2024

435

Design and mathematical analysis of activating transcriptional amplifiers that enable modular temporal control in

Calvin Lam

    Synthetic and Systems Biotechnology
    |October 23, 2023
    PubMed

    Keywords:
    AmplifiersCAR T cellSNIPRSelf-organizationSpatiotemporal controlSynthetic biologySynthetic developmentSynthetic immunotherapySynthetic receptorsTemporal controlsynNotch

    More Related Videos

    Gene Digital Circuits Based on CRISPR-Cas Systems and Anti-CRISPR Proteins10:46

    Gene Digital Circuits Based on CRISPR-Cas Systems and Anti-CRISPR Proteins

    Published on: October 18, 2022

    1.8K
    A Multilayer Microfluidic Platform for the Conduction of Prolonged Cell-Free Gene Expression11:23

    A Multilayer Microfluidic Platform for the Conduction of Prolonged Cell-Free Gene Expression

    Published on: October 6, 2019

    10.3K

    Related Concept Videos

    Amplifying Signals via Enzymatic Cascade01:22

    Amplifying Signals via Enzymatic Cascade

    When a ligand binds to a cell-surface receptor, the receptor's intracellular domain changes shape, which may either activate its enzyme function or allow its binding to other molecules. The initial signal is amplified by most signal transduction pathways. This means that a single ligand molecule can activate multiple molecules of a downstream target. Proteins that relay a signal are most commonly phosphorylated at one or more sites, activating or inactivating the protein. Kinases catalyze...
    8.5K
    BJT Amplifiers01:14

    BJT Amplifiers

    Bipolar Junction Transistors (BJTs) are pivotal components in amplifier circuits, functioning as voltage-controlled current sources in their active region. This characteristic allows them to efficiently control the collector current through variations in the base-emitter voltage. Essentially, BJTs amplify power due to their ability to take a weak input signal and output a much stronger signal.
    In BJT amplifier configurations, particularly in common-emitter setups, the transistor's role...
    480
    Small-Signal Analysis of BJT Amplifiers01:21

    Small-Signal Analysis of BJT Amplifiers

    Small signal analysis is a fundamental approach used in electronics to understand how a Bipolar Junction Transistor (BJT) amplifier processes signals. In the active region, the BJT is designed for linear amplification. The transistor's behavior under these conditions is governed by its instantaneous base-emitter voltage VBE, a sum of the DC bias VBE, and a small AC signal VBE, resulting in the collector current iC. Here, the collector current has a DC component and an AC component.
    1.1K
    Amplifying Signals via Second Messengers01:15

    Amplifying Signals via Second Messengers

    Many receptor binding ligands are hydrophilic; they do not cross the cell membrane but bind to cell-surface receptors. Thus, their message must be relayed by second messengers present in the cell cytoplasm. There are several second messenger pathways, each with its own way of relaying information. For example, the G protein-coupled receptors can activate both phosphoinositol and cyclic AMP (cAMP) second messenger pathways. The phosphoinositol pathway is active when the receptor induces...
    7.0K
    Cell Signaling Feedback Loops01:07

    Cell Signaling Feedback Loops

    Positive and negative feedback loops are crucial for regulating biological signaling systems. These feedback loops are processes that connect output signals to their inputs.
    Negative feedback loops
    Most signaling systems have negative feedback loops that can perform different functions such as output limiter, and adaptation.
    Output limiter
    Upon receiving an input signal, the cellular response rapidly increases until a threshold is reached. Beyond this threshold, a negative feedback loop...
    6.3K
    Design Example: Capacitance Multiplier Circuit01:20

    Design Example: Capacitance Multiplier Circuit

    In integrated circuit technology, a capacitance multiplier is often utilized to produce a larger capacitance value when a small physical capacitance falls short. This is achieved by a circuit that multiplies capacitance values by a factor of up to 1000, such that a 10-pF capacitor can replicate the performance of a 100-nF capacitor.
    The circuit illustrated in Figure 1 below incorporates two op-amps, with the first operating as a voltage follower and the second acting as an inverting amplifier.
    792