Related Experiment Video
Updated: Jul 12, 2025
Author Spotlight: Modeling an Aspect of Preeclampsia in Female Mice Using Hypoxic Human Placenta-Derived Small Extracellular Vesicles
Published on: January 26, 2024
Clinical value of mean platelet volume in predicting and diagnosing pre-eclampsia: a systematic review and
1The Second Clinical Medical College, Lanzhou University, Lanzhou, China.
Insights
Mean platelet volume (MPV) shows moderate predictive value for pre-eclampsia (PE) diagnosis, especially after 20 weeks gestation. Combining MPV with other markers may improve PE differentiation.
Area of Science:
- Obstetrics and Gynecology
- Hematology
- Diagnostic Accuracy Studies
Background:
- Pre-eclampsia (PE) is a severe pregnancy complication associated with thrombocytopenia and platelet dysfunction.
- Mean platelet volume (MPV) is a platelet function marker investigated for its predictive potential in PE diagnosis.
Purpose of the Study:
- To systematically evaluate the diagnostic accuracy of MPV for pre-eclampsia (PE).
- To assess MPV's predictive value in different gestational periods and identify optimal cut-off values.
Main Methods:
- A comprehensive literature search was conducted across multiple databases (PubMed, Embase, Cochrane Library, etc.) up to March 13, 2023.
- Diagnostic accuracy studies evaluating MPV for PE diagnosis were included.
- Meta-analysis techniques were used to pool sensitivity, specificity, and other diagnostic performance metrics.
Main Results:
- The pooled diagnostic accuracy for MPV in PE recognition showed a sensitivity of 0.676 and specificity of 0.710.
- Diagnostic accuracy was higher for PE diagnosed after 20 weeks gestation.
- Optimal diagnostic performance was observed when MPV cut-off values were between 9 and 10 fL, with SROC-AUC of 0.8856.
Conclusions:
- MPV demonstrates moderate predictive and diagnostic value for PE, particularly in later gestation.
- The sensitivity of MPV alone is limited; combining it with other markers could enhance PE differentiation.
- MPV cut-off values between 9 and 10 fL appear most effective for PE diagnosis.
Background:
Pre-eclampsia (PE) is a severe pregnancy complication. Thrombocytopenia and platelet dysfunction are common hematology disorders in PE. Previous studies considered mean platelet volume (MPV), a functional marker of platelets, as a potentially useful predictor for the diagnosis of PE.
Methods:
PubMed, China Biomedical Literature Database, Chinese National Knowledge Infrastructure, Embase, Wanfang, VIP, and Cochrane Library databases were searched to gather diagnostic trials evaluating the diagnosis of PE using MPV, from their inception to 13 March 2023. We also searched Google Scholar and Baidu.
Results:
A total of 22 studies from 20 articles were found. The pooled diagnostic accuracy of the MPV for PE recognition was as follows: sensitivity (SEN) 0.676 [95% confidence interval (CI) (0.658-0.694)], specificity (SPE) 0.710 [95% CI (0.703-0.717)], and diagnostic odds ratio (DOR) 7.012 [95% CI (4.226-11.636)], and the SROC-AUC and Q* indices were 0.7889 and 0.7262, respectively. The pooled SEN, SPE, and DOR of the diagnostic accuracy of MPV for PE before 16 weeks of gestation were 0.707 [95% CI (0.670-0.743)], 0.639 [95% CI (0.611-0.667)], and 4.026 [95% CI (2.727-5.943)], and the SROC-AUC and Q* indices were 0.7278 and 0.6753, respectively. For the interval of truncation values between 9 and 10 fl, the SROC-AUC and Q* indices for MPV were 0.8856 and 0.8162, respectively.
Conclusions:
Available evidence suggests that MPV has a moderate predictive and diagnostic value for PE, particularly in diagnosing after 20 weeks of gestation. The diagnostic accuracy is higher when the MPV cut-off falls between 9 and 10 fl. The sensitivity of MPV alone in diagnosing PE is not high, and the combination of other markers for predictive diagnosis may better differentiate PE.
Systematic Review Registration:
https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42023425154, identifier: CRD42023425154.
Related Concept Videos
01:13Sensitivity, Specificity, and Predicted Value
Sensitivity is the...
01:19Mitral Valve Prolapse III: Nursing Management
01:17Measurement of Blood Pressure