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Updated: Jul 12, 2025

Detection of Protein Palmitoylation in Cultured Hippocampal Neurons by Immunoprecipitation and Acyl-Biotin Exchange ABE
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Coordinated interplay between palmitoylation, phosphorylation and SUMOylation regulates kainate receptor surface

Busra P Yucel1, Enaam M Al Momany1, Ashley J Evans1

  • 1Centre for Synaptic Plasticity, School of Biochemistry, Biomedical Sciences Building, University of Bristol, Bristol, United Kingdom.

Frontiers in Molecular Neuroscience
|October 23, 2023
PubMed
Summary

Kainate receptor (KAR) palmitoylation stabilizes surface expression. Activity-dependent depalmitoylation triggers phosphorylation and SUMOylation, leading to KAR endocytosis and regulating neuronal excitability.

Keywords:
S-acylationSUMOylationkainate receptorsmembrane traffickingpalmitoylationphosphorylationpost-translational modification

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