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Related Experiment Video

Updated: Jul 12, 2025

Author Spotlight: Process Development for the Spray-Drying of Probiotic Bacteria and Evaluation of the Product Quality

Author Spotlight: Process Development for the Spray-Drying of Probiotic Bacteria and Evaluation of the Product Quality

Published on: April 7, 2023

Bacterium-like particles derived from probiotics: progress, challenges and prospects.

Xinyao Zhou¹, Mingchun Gao¹, Xinqi De¹

¹College of Veterinary Medicine, Northeast Agricultural University, Harbin, China.

Frontiers in Immunology

|October 23, 2023

Summary

Bacterium-like particles (BLPs) offer a safe and efficient system for delivering proteins and antigens. This review explores their composition, applications in vaccines, and potential for enhanced immunogenicity.

Keywords:

antigen delivery bacterium-like particles carrier-adjuvant lactic acid bacteria vaccine

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Last Updated: Jul 12, 2025

Author Spotlight: Process Development for the Spray-Drying of Probiotic Bacteria and Evaluation of the Product Quality

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Published on: April 7, 2023

Establishing Stable Binary Cultures of Symbiotic Saccharibacteria from the Oral Cavity

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Published on: April 13, 2021

Production and Visualization of Bacterial Spheroplasts and Protoplasts to Characterize Antimicrobial Peptide Localization

Production and Visualization of Bacterial Spheroplasts and Protoplasts to Characterize Antimicrobial Peptide Localization

Published on: August 11, 2018

Area of Science:

Biotechnology
Immunology
Materials Science

Background:

Bacterium-like particles (BLPs) are derived from food-grade Lactococcus lactis.
BLPs are hollow peptidoglycan structures inactivated by hot acid.
They possess advantageous properties like stability, high loading capacity, and mucosal delivery efficiency.

Purpose of the Study:

To provide a comprehensive understanding of BLP technical composition, characteristics, and applications.
To discuss the mechanisms by which BLPs induce adaptive immune responses.
To review recent advancements and future directions in BLP technology.

Main Methods:

Review of existing literature on BLPs.
Analysis of BLP properties and applications.
Discussion of immunogenicity enhancement strategies.

Main Results:

BLPs serve as effective delivery systems for proteins via protein anchors (PAs).
Applications include vaccine development, antigen purification, and enzyme immobilization.
BLPs demonstrate potential for superior adaptive immune responses.

Conclusions:

BLPs are versatile platforms for antigen delivery, particularly in subunit vaccines.
Further research is needed to enhance BLP immunogenicity.
Developments in Lactobacillus-derived BLPs and novel anchors show promise.