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A peptide bond covalently attaches amino acids through a dehydration reaction. One amino acid's carboxyl group and another amino acid's amino group combine, releasing a water molecule. The resulting bond is the peptide bond. The products that such linkages form are peptides. As more amino acids join this growing chain, the resulting chain is a polypeptide. Each polypeptide has a free amino group at one end. This end has the N-terminal, or the amino-terminal, and the other end has a free...

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Updated: Jul 12, 2025

Development of a Backbone Cyclic Peptide Library as Potential Antiparasitic Therapeutics Using Microwave Irradiation

Development of a Backbone Cyclic Peptide Library as Potential Antiparasitic Therapeutics Using Microwave Irradiation

Published on: January 26, 2016

Cyclic Peptides for Drug Development.

Xinjian Ji¹, Alexander L Nielsen¹, Christian Heinis¹

¹Institute of Chemical Sciences and Engineering, School of Basic Sciences, École Polytechnique Fédérale de Lausanne (EPFL), CH-1015, Lausanne, Switzerland.

Angewandte Chemie (International Ed. in English)

|October 23, 2023

Summary

This summary is machine-generated.

Cyclic peptides, abundant in nature, are increasingly developed into drugs using advanced technologies. This review highlights their therapeutic potential, technological progress, and future opportunities for unmet medical needs.

Keywords:

Cyclic Peptide Macrocycle Peptide Peptide Drug Peptide Therapeutics

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Published on: January 26, 2016

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Construction of Cyclic Cell-Penetrating Peptides for Enhanced Penetration of Biological Barriers

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Published on: September 19, 2022

Area of Science:

Biochemistry and Medicinal Chemistry
Drug Discovery and Development

Background:

Cyclic peptides are versatile molecules with diverse applications, including therapeutics, research tools, and food additives.
Recent advancements in peptide synthesis and drug development have led to a consistent approval rate of approximately one cyclic peptide drug annually.
Emerging technologies for screening peptide libraries and de novo ligand generation facilitate the development of cyclic peptide drugs independent of natural sources.

Purpose of the Study:

To review therapeutically relevant cyclic peptides, emphasizing those derived from natural sources.
To discuss the unique physicochemical and biological properties of cyclic peptides.
To explore recent technological innovations in cyclic peptide ligand development and identify future opportunities for addressing unmet medical needs.

Main Methods:

Literature review of natural and synthetic cyclic peptides with therapeutic relevance.
Analysis of technological advancements in peptide synthesis, screening, and design.
Discussion of case studies and examples of successful cyclic peptide drug development.

Main Results:

Cyclic peptides exhibit unique properties making them attractive drug candidates.
Technological progress has significantly expanded the scope for developing novel cyclic peptide therapeutics.
The field presents numerous opportunities for developing cyclic peptides to treat diseases with unmet medical needs.

Conclusions:

Cyclic peptides represent a significant and growing class of therapeutic agents.
Continued innovation in peptide technology promises to unlock further potential for cyclic peptide drugs.
Addressing unmet medical needs through cyclic peptide development remains a key focus for the field.