Related Experiment Video

Updated: Jul 12, 2025

Comparative Proteomic Analysis of Whole Kidney, Medulla, and Cortical Tubules in Diabetic Pathogenesis of Kidney Injury in Mice
10:37

Comparative Proteomic Analysis of Whole Kidney, Medulla, and Cortical Tubules in Diabetic Pathogenesis of Kidney Injury in Mice

Published on: May 2, 2025

200

PARAKID: Navigating the relation between paraproteins and kidney lesions: A multi-center retrospective observational

Mythri Shankar, Urmila Anandh, Swarnalatha Guditi

    Clinical Nephrology
    |October 23, 2023
    PubMed
    Abstract

    Insights

    Paraproteinemia causes diverse kidney diseases, with AL amyloidosis common in MGRS and cast nephropathy in multiple myeloma. Kidney replacement therapy is linked to older age and specific biopsy findings.

    Area of Science:

    • Nephrology
    • Hematology
    • Immunology

    Background:

    • Monoclonal gammopathy involves clonal proliferation of immunoglobulin-producing cells.
    • Kidney disease in paraproteinemia arises from malignant transformation, M protein properties, and host factors.

    Purpose of the Study:

    • To investigate the spectrum of kidney diseases associated with paraproteinemia.

    Main Methods:

    • Retrospective observational study across three tertiary care centers in Southern India.
    • Review of kidney biopsies from June 2020 to November 2022.
    • Inclusion of biopsies showing monotypic immunoglobulin or light chain restriction.

    Main Results:

    • 122 patients included, with an incidence of 2.4%.
    • AL amyloidosis was most frequent in monoclonal gammopathy of renal significance (MGRS); cast nephropathy in multiple myeloma (MM).
    • Histopathology revealed single lesions in 83.6%, double in 14.8%, and triple in 1.6% of cases.

    Conclusions:

    • Paraproteinemia is linked to various kidney lesions.
    • MGRS and MM typically affect individuals in their 6th decade and beyond.
    • Older age, elevated creatinine, hyperuricemia, hyperphosphatemia, multiple biopsy lesions, and cast nephropathy predict the need for kidney replacement therapy.

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