Isolated Castrate-resistant Prostate Cancer Metastasis to Both Adrenal Glands Detected on ⁶⁸Ga PSMA PET/CT

A 61-year-old male patient, who had undergone radical prostatectomy, underwent ⁶⁸Ga labeled prostate-specific membrane antigen (PSMA) positron emission tomography/computerized tomography (PET/CT) for evaluation of suspected biochemical recurrence of prostate cancer (PCa). PET/CT scan showed increased ⁶⁸Ga PSMA expressions in hypodense mass lesions in both adrenal gland localizations. An adrenal gland tru-cut biopsy was performed for the right side, which showed poor-differentiated carcinoma metastases associated with the patient's high-grade PCa. As far as we could determine based on an extensive literature search, this is the second case in which isolated adrenal metastasis was detected by ⁶⁸Ga PSMA PET/CT study in a patient with PCa.