Human platelet-derived growth factor-BB (rhPDGF-BB) with collagen matrix for sinus elevation without using a bone
Iya H Ghassib1, Muhammad H A Saleh1, Hom-Lay Wang1
1Department of Periodontics and Oral Medicine, University of Michigan School of Dentistry, Ann Arbor, Michigan, USA.
Clinical Advances in Periodontics
|October 23, 2023
Summary
This study shows that using recombinant human platelet-derived growth factor-BB (rh-PDGF-BB) with a collagen matrix in a sinus lift procedure can successfully increase bone height for dental implant placement. This method offers a faster alternative to traditional grafting techniques.
Area of Science:
- Oral and Maxillofacial Surgery
- Regenerative Dentistry
- Implantology
Background:
- A 38-year-old male patient presented with complications from tooth extraction, including a dislodged root segment, sinus wall fenestration, and limited bone height (3 mm).
- The patient required implant placement, necessitating bone augmentation in the sinus region.
Observation:
- A graftless sinus lift procedure was performed using a lateral window approach.
- Recombinant human platelet-derived growth factor-BB (rh-PDGF-BB) was applied to a wound dressing and placed in the sinus cavity with a dental implant.
- A split-thickness flap technique was used to elevate and repair the sinus membrane.
Findings:
- An 8-month follow-up using cone beam computed tomography revealed a vertical bone gain of 6.2 mm.
- Complete coverage of the dental implant was achieved.
- The approach demonstrated successful bone regeneration and implant integration.
Implications:
- This rh-PDGF-BB and collagen matrix approach offers a predictable and time-efficient alternative to traditional bone grafting for sinus lifts.
- It facilitates achieving adequate bone height for simultaneous implant placement.
- The technique shows promise for improving treatment outcomes in complex implant cases.
