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Updated: Jul 12, 2025
12:24
Murine Model of CD40-activation of B cells
Published on: March 5, 2010
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Uncovering the Potential of CD40 Agonism to Enhance Immune Checkpoint Blockade
1The Ohio State University James Comprehensive Cancer Center and Division of Medical Oncology, Columbus, Ohio.
Abstract:
In this CCR Translations, we discuss the therapeutic potential of CD40 agonism, which stimulates antigen-presenting cells (APC) to activate effector T and NK cells. CD40 agonism may lead to development of an interferon-activated, T cell-inflamed tumor microenvironment and has the potential to facilitate long-term response with immune checkpoint blockade. See related article by Weiss et al., p. 74.
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