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[Familial predisposition to multiple sclerosis].

J C Turpin, D Dubois, N Delasnerie-Laupretre

    Revue Neurologique
    |January 1, 1986
    PubMed
    Summary
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    Genetic factors influence multiple sclerosis (MS) susceptibility, with B7 and/or DR2 alleles playing a role. While not directly inherited, a predisposition to MS can be passed through families, influenced by environmental triggers.

    Area of Science:

    • Genetics
    • Immunology
    • Neurology

    Context:

    • Multiple Sclerosis (MS) is a complex neurological disease with suspected genetic components.
    • Previous research suggests associations between MS and specific human leukocyte antigen (HLA) alleles.
    • Understanding genetic predisposition is crucial for family counseling and risk assessment.

    Purpose:

    • To investigate the role of genetic factors and transmissibility in Multiple Sclerosis (MS) within families.
    • To identify specific genetic markers, such as B7 and DR2 alleles, associated with MS susceptibility.
    • To determine the inheritance patterns and the influence of genetic predisposition on disease manifestation and prognosis.

    Summary:

    • Seven families were analyzed to assess genetic influences on MS.

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  • A strong association was found between MS and B7 and/or DR2 alleles, which were conjointly transmissible.
  • The study indicates a predisposition heredity rather than direct genic inheritance, requiring a triggering factor for disease onset.
  • A favorable prognosis was observed in carriers of the specific haplotype within this cohort.
  • Family analysis revealed potential multi-generational impact, highlighting the complexity of MS inheritance.

    • Impact:

    • Identifies specific HLA alleles (B7, DR2) as significant markers for MS susceptibility.
    • Clarifies that MS inheritance is a predisposition, not a direct genetic trait, emphasizing the role of environmental factors.
    • Provides crucial information for genetic counseling of families with a history of MS and related conditions like insulin-dependent diabetes.
    • Suggests that the carrier haplotype influences disease presentation and prognosis, offering insights into disease management.