Related Experiment Video
Updated: Jul 12, 2025
08:56
Isolation of Murine Embryonic Hemogenic Endothelial Cells
Published on: June 17, 2016
11.5K
Identification and characterization of human hematopoietic mesoderm
Yuqi Wen1,2,3, Jingjing Zhao1,2,3, Runqing Zhang1,2,3
1State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, 300020, China.
Science China. Life Sciences
|October 23, 2023
Summary
Researchers identified early human hematopoietic mesoderm (HM) cells, revealing BMP4
Area of Science:
- Developmental Biology
- Stem Cell Biology
- Hematopoiesis
Background:
- The early human embryo contains mesoderm, a cell type with diverse developmental potentials.
- The emergence of hematopoietic lineage bias within embryonic mesoderm is not well understood.
Purpose of the Study:
- To identify and characterize human hematopoietic mesoderm (HM) cells.
- To elucidate the molecular mechanisms governing HM cell specification.
Main Methods:
- Single-cell transcriptomic analysis of human mesoderm cells.
- In vitro studies involving gene inhibition and enhancement.
Main Results:
- Identified specific molecular features of human hematopoietic mesoderm (HM) cells.
- BMP4 was found to be crucial for HM specification and a reliable marker.
- HDAC1 regulates BMP4 expression via enhancer deacetylation, impacting HM specification.
Conclusions:
- This study defines human hematopoietic mesoderm (HM) cells.
- New regulatory mechanisms for human hematopoietic development involving HDAC1 and BMP4 were uncovered.
More Related Videos
Related Concept Videos
01:21Hematopoiesis
5.3K
The process of blood cell formation is called hematopoiesis. Hematopoiesis starts early during development, on the seventh day of embryogenesis. This phase of hematopoiesis is called the primitive wave, wherein the extraembryonic yolk sac allows the production of erythroid cells and endothelial cells from a common precursor called hemangioblast. The erythroid cells provide oxygen to support the growth of the rapidly dividing embryo. Hemangioblasts later develop into hematopoietic stem cells or...
5.3K
01:20Overview of Hematopoiesis
4.1K
Hematopoiesis, or blood cell production, is a vital biological process that begins early in embryonic development and continues throughout life. This process generates the various types of cells found in blood, including red blood cells, white blood cells, and platelets from hematopoietic stem cells (HSCs).
Developmental Phases of Hematopoiesis
Initially, HSCs are formed in the embryonic yolk sac, a critical site for early blood cell production. These stem cells subsequently migrate to other...
Developmental Phases of Hematopoiesis
Initially, HSCs are formed in the embryonic yolk sac, a critical site for early blood cell production. These stem cells subsequently migrate to other...
4.1K
01:19Multipotency of Hematopoietic Stem Cells
3.1K
The hematopoietic stem cells or HSCs are multipotent, meaning they can differentiate and give rise to all blood and immune cells. HSCs are maintained in the quiescent stage until an external stimulus initiates their differentiation. The multipotent HSCs exist as two heterogeneous populations, long-term repopulating cells (LTRC) and short-term repopulating cells (STRC). The two HSC populations have different surface markers or receptors and are classified based on quiescence and long-term...
3.1K
01:34Production of Formed Elements
1.4K
Hemangioblasts are multipotent stem cells originating from the mesoderm. They give rise to hematopoietic stem cells (HSCs), which undergo hematopoiesis to produce all the formed elements of blood. This process is regulated by a complex network of hematopoietic growth factors, including transcription factors, growth factors, and cytokines. These factors stimulate the HSCs to divide and differentiate, though some HSCs remain undifferentiated to maintain a self-renewing pool.
Most HSCs commit to...
Most HSCs commit to...
1.4K