Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

The cryoglobulinemic vasculitis.

R Cattaneo, M G Fenini, F Facchetti

    La Ricerca in Clinica E in Laboratorio
    |April 1, 1986
    PubMed
    Summary
    This summary is machine-generated.

    Essential mixed cryoglobulinemia (EMC) patients exhibit vasculitis, with no major differences between type II and III. Kidney and skin biopsies reveal glomerulonephritis and leukocytoclastic vasculitis, suggesting complex pathogenetic mechanisms in EMC.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Correction to: A practical algorithmic approach to mature aggressive B cell lymphoma diagnosis in the double/triple hit era: selecting cases, matching clinical benefit.

    Virchows Archiv : an international journal of pathology·2019
    Same author

    A practical algorithmic approach to mature aggressive B cell lymphoma diagnosis in the double/triple hit era: selecting cases, matching clinical benefit : A position paper from the Italian Group of Haematopathology (G.I.E.).

    Virchows Archiv : an international journal of pathology·2019
    Same author

    Dose-adjusted EPOCH plus rituximab improves the clinical outcome of young patients affected by double expressor diffuse large B-cell lymphoma.

    Leukemia·2019
    Same author

    Clinical features and outcomes of hepatocellular carcinoma in Caucasian cirrhotic patients on long-term analogue therapy for hepatitis B.

    Alimentary pharmacology & therapeutics·2018
    Same author

    Histopathological study of perilesional skin in patients diagnosed with nonmelanoma skin cancer.

    Clinical and experimental dermatology·2015
    Same author

    Rosettes and other white shiny structures in polarized dermoscopy: histological correlate and optical explanation.

    Journal of the European Academy of Dermatology and Venereology : JEADV·2015
    Same journal

    Increase of plasma tissue-plasminogen activator antigen levels after induced abortion.

    La Ricerca in clinica e in laboratorio·1991
    Same journal

    Role of prostaglandin E2 on defective interferon-gamma production during type B acute viral hepatitis.

    La Ricerca in clinica e in laboratorio·1991
    Same journal

    The use of recombinant factor VIII in the management of hemophilia.

    La Ricerca in clinica e in laboratorio·1991
    Same journal

    The functioning liver mass.

    La Ricerca in clinica e in laboratorio·1991
    Same journal

    Liver system. V. Activation-extinction line of cyclic hepatocyte activities.

    La Ricerca in clinica e in laboratorio·1991
    Same journal

    Liver system. IV. More on the liver micro-unit: physics and geometry of its action.

    La Ricerca in clinica e in laboratorio·1991
    See all related articles

    Area of Science:

    • Nephrology
    • Rheumatology
    • Immunology

    Background:

    • Essential mixed cryoglobulinemia (EMC) is a systemic vasculitis characterized by cryoprecipitable immune complexes.
    • EMC is classified into types based on immunoglobulin composition, primarily type II and type III.

    Purpose of the Study:

    • To evaluate clinical manifestations and histopathological findings in patients with essential mixed cryoglobulinemia.
    • To compare clinical and laboratory features between type II and type III EMC.
    • To investigate the nature of blood vessel involvement in EMC.

    Main Methods:

    • Retrospective analysis of 38 patients with EMC (16 type II, 22 type III).
    • Clinical data collection including manifestations of cutaneous and visceral vasculitis.

    Related Experiment Videos

  • Histopathological examination of kidney biopsies (n=9) and skin biopsies (n=11).

    • Main Results:

    • Nearly all patients presented with clinical signs of vasculitis.
    • No significant clinical or laboratory differences were observed between type II and type III EMC.
    • Kidney biopsies showed various forms of glomerulonephritis; skin biopsies most commonly revealed leukocytoclastic vasculitis.
    • Thrombus-like deposits, similar to those in type I cryoglobulinemia, were found in 3 patients.

    Conclusions:

    • EMC involves complex blood vessel pathology with potential for multiple pathogenetic mechanisms.
    • Histopathological findings underscore the systemic nature of vasculitis in EMC.
    • Further research is needed to elucidate the distinct pathogenetic pathways in EMC subtypes.