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Evaluation of Right Ventricular Function in Experimental Models of Pulmonary Arterial Hypertension
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Right ventricular global strain in patients with hypertrophic cardiomyopathy with and without right ventricular

Yufan Qian1, Xinghan Zhao2, Bing-Hua Chen1

  • 1Department of Radiology, Ren Ji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200127, China.

European Journal of Radiology
|October 23, 2023
PubMed

Insights

Right ventricular global longitudinal strain (RV GLS) and global circumferential strain (RV GCS) predict adverse events in hypertrophic cardiomyopathy (HCM) patients, regardless of RV hypertrophy (RVH). RV GLS is key for RVH patients, while RV GCS is crucial for non-RVH patients.

Area of Science:

  • Cardiology
  • Cardiovascular Imaging
  • Cardiac MRI

Background:

  • Hypertrophic cardiomyopathy (HCM) is a genetic heart disease characterized by left ventricular hypertrophy.
  • The prognostic role of right ventricular (RV) function, particularly global strains, in HCM patients remains incompletely understood, especially concerning RV hypertrophy (RVH).

Purpose of the Study:

  • To investigate the prognostic significance of RV global longitudinal strain (GLS) and RV global circumferential strain (GCS) in HCM patients.
  • To determine if these RV strain parameters provide additional predictive value in HCM patients with and without RV hypertrophy (RVH).

Main Methods:

  • A retrospective analysis of 358 HCM patients who underwent cardiac MRI (CMR) and follow-up.
  • RV hypertrophy (RVH) defined as maximal RV wall thickness ≥ 5 mm.
  • RV GLS and RV GCS measured using CMR feature tracking; composite endpoint included mortality, aborted sudden cardiac death (SCD), and heart failure readmission.

Main Results:

  • Over a median follow-up of 25 months, 49 patients reached the composite endpoint.
  • RV GLS was an independent predictor of adverse events in HCM patients with RVH (HR: 1.123, P=0.002).
  • RV GCS was an independent predictor in HCM patients without RVH (HR: 1.174, P=0.015); both improved model discrimination.

Conclusions:

  • RV GLS and RV GCS are independent predictors of adverse outcomes in HCM patients, stratified by RVH status.
  • RV GLS in the RVH group and RV GCS in the non-RVH group offer incremental prognostic value for risk stratification in HCM.
Abstract

Keywords:
Cardiac magnetic resonance feature trackingHypertrophic CardiomyopathyRight ventricular hypertrophy

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