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Updated: Jul 12, 2025

Identification of Circular RNAs using RNA Sequencing
08:25

Identification of Circular RNAs using RNA Sequencing

Published on: November 14, 2019

12.3K

Circular RNA_0000285: A novel double-edged sword circular RNA in human malignancies

Mohsen Ahmadi1, Firouzeh Morshedzadeh2, Soudeh Ghafouri-Fard1

  • 1Department of Medical Genetics, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Pathology, Research and Practice
|October 23, 2023
PubMed

Insights

Circular RNAs (circRNAs), like circ_0000285, play a role in cancer by interacting with microRNAs (miRNAs). This review summarizes circ_0000285's oncogenic effects and potential interactions in various cancers.

Area of Science:

  • Molecular Biology
  • Genetics
  • Oncology

Background:

  • Circular RNAs (circRNAs) are covalently closed RNA molecules formed by back splicing.
  • Dysregulated circRNAs, such as circ_0000285, impact gene transcription via microRNA (miRNA) interactions.
  • circ_0000285, derived from the HIPK3 gene, acts as a competing endogenous RNA for multiple miRNAs.

Purpose of the Study:

  • To review the oncogenic role of circ_0000285 in human cancers.
  • To summarize experimental evidence from cell lines, animal models, and human tissues.
  • To identify potential miRNA and RNA-binding protein interactions with circ_0000285.

Main Methods:

  • Literature review of studies on circ_0000285 in cancer.
  • Analysis of experimental data from in vitro, in vivo, and human studies.
  • Bioinformatic prediction of miRNA and RNA-binding protein targets.

Main Results:

  • circ_0000285 is frequently dysregulated in various cancers.
  • circ_0000285 is associated with poor prognosis and clinicopathological features in cancer patients.
  • circ_0000285 acts as a competing endogenous RNA for several miRNAs, influencing cancer progression.

Conclusions:

  • circ_0000285 exhibits significant oncogenic effects across multiple cancer types.
  • Understanding circ_0000285 interactions may offer novel therapeutic strategies for cancer.
  • Further research into circ_0000285 targets could reveal new insights into cancer mechanisms.
Keywords:
BioinformaticsBiomarkersCancerCirc_0000285Circular RNADiagnosisMiRNASurvival

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