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Heat exposure intervention, anxiety level, and multi-omic profiles: A randomized crossover study.
Wen Fang1, Linfeng Liu2, Bo Yin2
1Division of Sports Science & Physical Education, Tsinghua University, Beijing, China.
Environment International
|October 23, 2023
Summary
High temperatures from climate change increase anxiety. Heat exposure activates the HPA axis, causing inflammation and oxidative stress, leading to anxiety. Immediate climate action is crucial.
Area of Science:
- Environmental Health
- Neuroscience
- Metabolomics
Background:
- Climate change exacerbates high-temperature weather, impacting health and the nervous system.
- The precise mechanisms linking heat stress to mental health, particularly anxiety, are not well understood.
Purpose of the Study:
- To investigate the impact of heat exposure on anxiety levels.
- To elucidate the underlying biological mechanisms of heat stress-induced anxiety.
Main Methods:
- A randomized controlled trial involving 20 college students in Beijing.
- Analysis of serum metabolites and gene expression using metabolomic and transcriptomic approaches.
- ELISA measurements to explore biological pathways.
Main Results:
- A 1.5-hour heat exposure intervention significantly elevated anxiety levels.
- Heat stress-induced anxiety is linked to HPA axis activation, inflammation, and oxidative stress.
- Biomarkers include BDNF, GABA, and glucocorticoids, indicating neurotransmitter imbalance.
Conclusions:
- Established a causal relationship between heat stress and anxiety.
- Heat stress triggers HPA axis activation, metabolic changes, inflammation, and oxidative stress, culminating in anxiety.
- Highlights the overlooked health costs of climate change and the urgency of climate action.
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