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Non-consummatory behavior signals predict aversion-resistant alcohol drinking in head-fixed mice.

Nicholas M Timme1, Cherish E Ardinger1, Seth D C Weir1

  • 1Department of Psychology, Indiana University - Purdue University Indianapolis, 402 N. Blackford St, LD 124, Indianapolis, IN, 46202, USA.

Neuropharmacology
|October 23, 2023
PubMed
Summary

Head-fixed mice show varied levels of aversion-resistant drinking, continuing alcohol consumption despite bitter additives. Non-consummatory behaviors, like paw and snout movements, correlate with this drinking behavior, offering insights into alcohol use disorder models.

Keywords:
AlcoholAversion-resistant drinkingBehavioral analysisFrontloadingHead-fixationMouse

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Area of Science:

  • Neuroscience
  • Behavioral Science
  • Pharmacology

Background:

  • Alcohol use disorder (AUD) is characterized by continued alcohol consumption despite negative consequences, termed aversion-resistant drinking.
  • Understanding the neurobiological underpinnings of aversion-resistant drinking is crucial for developing effective treatments for AUD.
  • Head-fixed rodent models offer precise control and measurement capabilities for studying complex behaviors like aversion resistance.

Purpose of the Study:

  • To quantify aversion-resistant drinking in head-fixed mice (both female and male C57BL/6J strains).
  • To correlate non-consummatory behaviors (e.g., body movements) with the degree of aversion-resistant drinking.
  • To establish a foundation for future electrophysiological studies investigating neural circuits involved in aversion resistance.

Main Methods:

  • Head-fixed female and male C57BL/6J mice were presented with 20% (v/v) alcohol adulterated with varying concentrations of quinine.
  • High-resolution video recordings captured drinking behavior, and machine vision tools tracked body parts and movements.
  • Consumption data was analyzed in conjunction with recorded non-consummatory behaviors.

Main Results:

  • Head-fixed mice displayed heterogeneous levels of aversion-resistant drinking.
  • Specific non-consummatory behaviors, including paw and snout movements, were significantly related to the intensity of aversion-resistant drinking.
  • The study successfully demonstrated aversion-resistant drinking in this head-fixed model.

Conclusions:

  • Head-fixed mice provide a viable model for studying aversion-resistant drinking relevant to alcohol use disorder.
  • Non-consummatory behaviors can serve as measurable indicators of perceived aversiveness in this paradigm.
  • This research paves the way for advanced neurophysiological investigations into the neural computations driving aversion-resistant drinking.