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Gram-negative bacillary meningitis in the adult: review of 39 cases

D J Gower, A A Barrows, D L Kelly

    Southern Medical Journal
    |December 1, 1986
    PubMed

    Insights

    This study reviewed gram-negative meningitis in adults from 1976-1984. Chloramphenicol use correlated with increased mortality, suggesting it is not an optimal treatment for this condition.

    Area of Science:

    • Neuroscience
    • Infectious Diseases
    • Clinical Medicine

    Background:

    • Gram-negative meningitis is a serious infection affecting the central nervous system.
    • Understanding treatment efficacy and mortality trends is crucial for patient outcomes.

    Observation:

    • A review of 45 episodes of gram-negative meningitis in 39 adult patients between 1976 and 1984 was conducted.
    • Common causes included dura-arachnoid disruption, septic episodes, and bacterial mastoiditis.

    Findings:

    • The overall mortality rate for gram-negative meningitis during this period was 35.9%.
    • Intrathecal antibiotic courses varied, with 13 patients receiving full courses and 8 receiving abbreviated courses.
    • The use of chloramphenicol was associated with poorer patient outcomes.

    Implications:

    • Findings suggest chloramphenicol may be detrimental for treating gram-negative meningitis.
    • Further research into optimal antibiotic strategies for gram-negative meningitis is warranted.
    • This data highlights the importance of evaluating antibiotic effectiveness in clinical practice.

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