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Updated: Jul 12, 2025

A Multiplexed Luciferase-based Screening Platform for Interrogating Cancer-associated Signal Transduction in Cultured Cells
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Exploiting signaling rewiring in cancer cells with co-existing oncogenic drivers

Roberto Chiarle1,2, Chiara Ambrogio2

  • 1Department of Pathology, Boston Children's Hospital and Harvard Medical School, Boston, MA, USA.

Molecular Oncology
|October 24, 2023
PubMed

Insights

Targeted cancer therapies inhibiting driver oncogenes offer new ways to study tumor evolution. Understanding how cancer adapts to these treatments is key to developing more effective, personalized cancer medicines.

Area of Science:

  • Oncology
  • Cancer Biology
  • Molecular Biology

Background:

  • Targeted therapies focusing on specific driver oncogenes are revolutionizing cancer treatment.
  • Selective inhibitors provide new experimental and clinical approaches to cancer research.

Purpose of the Study:

  • To explore the dynamics of cancer development and treatment response using targeted therapies.
  • To investigate how cancer cells adapt and evolve under selective pressure from inhibitors.

Main Methods:

  • Utilizing selective inhibitors to target key driver oncogenes in vitro and in vivo.
  • Conducting longitudinal and clonal evolutionary studies to track cancer cell adaptation.

Main Results:

  • Direct inhibition of driver oncogenes allows for detailed observation of cancer cell adaptation.
  • Cancer cells exhibit rewiring and exploitation of signaling dependencies in response to treatment.

Conclusions:

  • Targeted therapies present a unique opportunity to study cancer evolution in real-time.
  • Resolving the challenges of treatment adaptation is crucial for advancing personalized cancer therapies.
Keywords:
driver oncogenesdrug resistancesignaling rewiring

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