Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Circadian Rhythms and Gene Regulation02:19

Circadian Rhythms and Gene Regulation

4.1K
The biological clock is involved in many aspects of regulating complex physiology in all animals. It was in 1935 when German zoologists, Hans Kalmus and Erwin Bünning, discovered the existence of circadian rhythm in Drosophila melanogaster. However, the internal molecular mechanisms behind the circadian clock remained a mystery until 1984, when Jeffrey C. Hall, Michael Rosbash, and Michael W. Young discovered the expression of the Per gene oscillating over a 24-hour cycle. In subsequent...
4.1K
Chronopharmacokinetics: Circadian Rhythms and Influence on Drug Response01:15

Chronopharmacokinetics: Circadian Rhythms and Influence on Drug Response

69
Circadian rhythms are cyclic changes that are crucial in plasma drug concentrations. Various standard circadian parameters, including core body temperature, heart rate, and other cardiovascular factors, directly impact disease states and the therapeutic response to drug therapy.
The time of drug administration is an important factor to consider, as it can influence the toxic dose of a drug. For example, a study conducted by Prins et al. in 1997 examined the effects of the timing of...
69
Inflammatory Response01:28

Inflammatory Response

2.1K
An inflammatory response is a localized, nonspecific immune reaction that occurs when a tissue is injured. It is characterized by redness, swelling, heat, and pain, which are commonly called the cardinal signs and symptoms of inflammation. Inflammation can sometimes result in a loss of function.
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
2.1K
Sleep-Wake Cycles01:24

Sleep-Wake Cycles

1.4K
Sleep is an essential physiological process vital to maintaining overall well-being. The reticular activating system (RAS), a network of neurons in the brainstem, regulates wakefulness and sleep. While it may seem passive, sleep consists of distinct cycles, each with its unique characteristics and functions. Two key sleep phases are non-rapid eye movement (NREM) and  rapid eye movement (REM).
NREM Sleep
NREM sleep comprises four progressive stages that seamlessly merge:
1.4K
Inflammation01:38

Inflammation

53.7K
Overview
53.7K
Understanding Sleep01:11

Understanding Sleep

236
Sleep, an essential biological state, involves significant reductions in physical activity, sensory awareness, and interaction with the environment. This complex physiological process is primarily regulated by specific brain regions, notably the hypothalamus and pons, which govern the sleep-wake cycle or circadian rhythm.
The circadian rhythm, a nearly 24-hour cycle, is deeply influenced by environmental light cues. Light exposure directly affects the hypothalamus, which in turn regulates...
236

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

1-Dodecyl-3-methylimidazolium bis(trifluoromethanesulfonyl) imide Interface Design  for Stable and Effective Perovskite Solar Cells.

ChemSusChem·2026
Same author

Impaired sleep resilience underlies transient neural instability in insomnia disorder.

iScience·2026
Same author

Fluorescence Tuning of Carbon Dots from Red to Blue via UV-Induced Photochemical Etching.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2026
Same author

Liberating Free Coal Molecules by Exfoliation of Aggregated Coal.

ACS omega·2026
Same author

Osteoporosis in children and adolescents with transfusion-dependent thalassemia and the diagnostic value of different indicators.

BMC pediatrics·2026
Same author

Optimised triangular pheromone traps for multi-season monitoring of <i>Tuta absoluta</i> in protected tomato systems.

Bulletin of entomological research·2026

Related Experiment Video

Updated: Jul 12, 2025

The Use of Mouse Splenocytes to Assess Pathogen-associated Molecular Pattern Influence on Clock Gene Expression
06:50

The Use of Mouse Splenocytes to Assess Pathogen-associated Molecular Pattern Influence on Clock Gene Expression

Published on: July 24, 2018

7.5K

Circadian cycle and neuroinflammation.

Xinzi Xu1, Junli Wang2, Guohua Chen2

  • 1College of Clinical Chinese Medicine, Hubei University of Chinese Medicine, Wuhan 430065, China.

Open Life Sciences
|October 24, 2023
PubMed
Summary

Circadian rhythms regulate immune cells and neuroinflammation. Disruptions to the body clock can worsen neuroinflammatory conditions by affecting glial cells and immune responses.

Keywords:
astrocytecircadian rhythmmicroglianeuroinflammation

More Related Videos

Detection of MicroRNAs in Microglia by Real-time PCR in Normal CNS and During Neuroinflammation
13:36

Detection of MicroRNAs in Microglia by Real-time PCR in Normal CNS and During Neuroinflammation

Published on: July 23, 2012

19.5K
Improved 3D Hydrogel Cultures of Primary Glial Cells for In Vitro Modelling of Neuroinflammation
09:19

Improved 3D Hydrogel Cultures of Primary Glial Cells for In Vitro Modelling of Neuroinflammation

Published on: December 8, 2017

14.7K

Related Experiment Videos

Last Updated: Jul 12, 2025

The Use of Mouse Splenocytes to Assess Pathogen-associated Molecular Pattern Influence on Clock Gene Expression
06:50

The Use of Mouse Splenocytes to Assess Pathogen-associated Molecular Pattern Influence on Clock Gene Expression

Published on: July 24, 2018

7.5K
Detection of MicroRNAs in Microglia by Real-time PCR in Normal CNS and During Neuroinflammation
13:36

Detection of MicroRNAs in Microglia by Real-time PCR in Normal CNS and During Neuroinflammation

Published on: July 23, 2012

19.5K
Improved 3D Hydrogel Cultures of Primary Glial Cells for In Vitro Modelling of Neuroinflammation
09:19

Improved 3D Hydrogel Cultures of Primary Glial Cells for In Vitro Modelling of Neuroinflammation

Published on: December 8, 2017

14.7K

Area of Science:

  • Neuroscience
  • Immunology
  • Chronobiology

Background:

  • The circadian cycle is a fundamental biological process essential for organismal evolution.
  • Circadian rhythm disorders are linked to neuroinflammation, glial cell activation, and peripheral immune responses.
  • Understanding the interplay between circadian rhythms and the immune system is crucial for neuroinflammation research.

Purpose of the Study:

  • To review recent advancements in neuroinflammation and circadian rhythm research.
  • To explore the influence of circadian rhythmicity on microglia, astrocytes, and peripheral immune function.
  • To elucidate the potential mechanisms underlying the circadian regulation of neuroinflammation.

Main Methods:

  • Literature review of recent studies on neuroinflammation and circadian rhythms.
  • Analysis of research on the role of circadian rhythmicity in glial cell function (microglia and astrocytes).
  • Investigation of the impact of circadian rhythm disorders on peripheral immune responses.

Main Results:

  • Circadian rhythms are integral to immune cell proliferation, migration, and activation.
  • Disrupted circadian rhythms exacerbate neuroinflammation through glial activation and altered peripheral immunity.
  • Specific mechanisms linking circadian rhythmicity to neuroinflammation are being elucidated.

Conclusions:

  • Circadian rhythmicity significantly impacts neuroinflammation by modulating glial cells and peripheral immunity.
  • Maintaining circadian balance is vital for preventing or mitigating neuroinflammatory conditions.
  • Further research into the mechanistic links can reveal therapeutic targets for neuroinflammatory diseases.