Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Drusen volume and reticular pseudodrusen volume from optical coherence tomography with deep learning as risk factors for progression to late age-related macular degeneration in eyes with reticular pseudodrusen and contralateral macular neovascularisation.

The British journal of ophthalmology·2026
Same author

Interpretable Deep Learning for OCT-Based Diagnosis of Vitreoretinal Lymphoma Versus Uveitis.

Translational vision science & technology·2026
Same author

Endogenous Nocardia Nova Panophthalmitis Masquerading as Malignancy: A Clinicopathologic Report.

Retinal cases & brief reports·2026
Same author

Comprehensive Adult Medical Eye Evaluation Preferred Practice Pattern®.

Ophthalmology·2026
Same author

Elevated Retinal Neovascularization on Widefield Optical Coherence Tomography Angiography Predicts Complications in High-Risk Proliferative Diabetic Retinopathy.

American journal of ophthalmology·2025
Same author

Long-term outcomes of combination systemic and intravitreal antiviral therapy in the management of acute retinal necrosis.

Journal of ophthalmic inflammation and infection·2025

Related Experiment Video

Updated: Jul 12, 2025

Evaluation of Capillary and Other Vessel Contribution to Macular Perfusion Density Measured with Optical Coherence Tomography Angiography
07:18

Evaluation of Capillary and Other Vessel Contribution to Macular Perfusion Density Measured with Optical Coherence Tomography Angiography

Published on: February 18, 2022

1.8K

Perfused and Nonperfused Microaneurysms Identified and Characterized by Structural and Angiographic OCT.

Min Gao1, Tristan T Hormel1, Yukun Guo1,2

  • 1Casey Eye Institute, Oregon Health & Science University, Portland, Oregon.

Arxiv
|October 24, 2023
PubMed
Summary

Fully perfused microaneurysms (MAs) detected with OCT/OCTA are more likely to correlate with diabetic macular edema (DME). This finding helps understand MA contribution to DME in diabetic retinopathy.

Keywords:
OCTOCT angiographyPerfused and nonperfused microaneurysms

More Related Videos

Nondestructive Monitoring of Degradable Scaffold-Based Tissue-Engineered Blood Vessel Development Using Optical Coherence Tomography
11:12

Nondestructive Monitoring of Degradable Scaffold-Based Tissue-Engineered Blood Vessel Development Using Optical Coherence Tomography

Published on: October 3, 2018

5.7K
Retinal Vascular Reactivity as Assessed by Optical Coherence Tomography Angiography
07:23

Retinal Vascular Reactivity as Assessed by Optical Coherence Tomography Angiography

Published on: March 26, 2020

7.6K

Related Experiment Videos

Last Updated: Jul 12, 2025

Evaluation of Capillary and Other Vessel Contribution to Macular Perfusion Density Measured with Optical Coherence Tomography Angiography
07:18

Evaluation of Capillary and Other Vessel Contribution to Macular Perfusion Density Measured with Optical Coherence Tomography Angiography

Published on: February 18, 2022

1.8K
Nondestructive Monitoring of Degradable Scaffold-Based Tissue-Engineered Blood Vessel Development Using Optical Coherence Tomography
11:12

Nondestructive Monitoring of Degradable Scaffold-Based Tissue-Engineered Blood Vessel Development Using Optical Coherence Tomography

Published on: October 3, 2018

5.7K
Retinal Vascular Reactivity as Assessed by Optical Coherence Tomography Angiography
07:23

Retinal Vascular Reactivity as Assessed by Optical Coherence Tomography Angiography

Published on: March 26, 2020

7.6K

Area of Science:

  • Ophthalmology
  • Medical Imaging
  • Diabetic Retinopathy Research

Background:

  • Diabetic retinopathy (DR) is a leading cause of vision loss.
  • Microaneurysms (MAs) are early indicators of DR, but their association with macular edema is not fully understood.
  • Optical Coherence Tomography Angiography (OCTA) allows for detailed visualization of vascular changes in the retina.

Approach:

  • A retrospective cross-sectional study analyzed OCT and OCTA scans from 99 participants with DR.
  • Microaneurysms were identified and classified based on the presence and extent of blood flow signal (perfused vs. nonperfused).
  • The association between MA perfusion status and the presence of retinal fluid (diabetic macular edema) was quantitatively assessed.

Key Points:

  • OCT/OCTA identified 308 MAs, classified as fully perfused, partially perfused, or nonperfused.
  • Fully perfused MAs were significantly more likely to be associated with local retinal fluid compared to other types.
  • The volume of associated retinal fluid was larger for fully perfused MAs.
  • OCT/OCTA demonstrated high sensitivity in detecting MAs compared to fundus photography and fluorescein angiography.

Conclusions:

  • OCT-identified microaneurysms with detectable blood flow on OCTA are more strongly associated with diabetic macular edema.
  • This classification of MAs based on perfusion status may improve understanding and management of DME in diabetic patients.
  • OCTA provides valuable insights into the functional characteristics of MAs in DR.