Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Role of Hippocampus in Memory01:19

Role of Hippocampus in Memory

276
The hippocampus, a critical brain structure, plays an essential role in memory processing, particularly in the formation and retrieval of memory. This small, seahorse-shaped region is located within the medial temporal lobe, with one hippocampus in each brain hemisphere. Experimental studies involving lesions in the hippocampi of rats have demonstrated significant impairments in tasks such as object recognition and maze navigation, indicating the hippocampus involvement in both recognition and...
276
Role of Amygdala in Memory01:16

Role of Amygdala in Memory

254
The amygdala is a small, almond-shaped structure responsible for processing and storing memories, particularly those linked to emotions like fear and stress. It plays an essential role in the brain's response to emotionally significant events and often enhances memory formation by triggering stress hormone release. The amygdala is vital for encoding and retrieving memories associated with fear or stress, a process that is adaptive by helping organisms avoid dangerous situations.
One of the...
254
Diencephalon: Anatomical Regions01:30

Diencephalon: Anatomical Regions

2.1K
The diencephalon, etymologically translated as 'through brain,' plays an integral role as the conduit between the cerebrum and the vast extent of the nervous system. However, the olfactory system is an exception, as it interfaces directly with the cerebrum. The diencephalon, deeply ensconced beneath the cerebrum, primarily consists of three paired structures — the thalamus, hypothalamus, and epithelamus. It also includes accessory structures such as the subthalamus, which houses the...
2.1K
Functional Brain Systems: Limbic System01:15

Functional Brain Systems: Limbic System

2.9K
The limbic system, often called the "emotional brain," is a complex set of structures located deep within the brain. The intricate network of the limbic system supports a wide range of psychological functions, from emotional regulation to memory formation and sensory processing. This functional brain region encompasses specific parts of the diencephalon and the cerebrum, integrating the higher mental functions of the cerebral cortex with the primitive emotional responses of the deep brain...
2.9K
Olfaction01:25

Olfaction

44.4K
The sense of smell is achieved through the activities of the olfactory system. It starts when an airborne odorant enters the nasal cavity and reaches olfactory epithelium (OE). The OE is protected by a thin layer of mucus, which also serves the purpose of dissolving more complex compounds into simpler chemical odorants. The size of the OE and the density of sensory neurons varies among species; in humans, the OE is only about 9-10 cm2.
The olfactory receptors are embedded in the cilia of the...
44.4K
Higher Mental Functions of Brain: Learning and Memory01:26

Higher Mental Functions of Brain: Learning and Memory

837
Memory is one of the most vital higher mental functions of the brain. Memory is closely related to learning because it enables us to retain information and experiences from our past to use them in our present life. It also helps us to remember facts, events, and skills, such as riding a bike or swimming. There are two types of memory — declarative memory, which involves memorizing facts or events, and procedural memory, which enables us to remember how to do something like writing or...
837

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Volitional cocaine taking engages distinct medium spiny neuron and astrocyte transcriptional programs in the rat nucleus accumbens.

bioRxiv : the preprint server for biology·2026
Same author

Bifidobacterium bifidum TMC3115-RAW264.7 cell conditioned mediums promote the synaptic development of primary hippocampal neuron via activating IL-6/JAK2/STAT3 signaling pathway.

Brain, behavior, and immunity·2026
Same author

Chronic semaglutide alters ingestive behavior without impairing taste function in mice.

Molecular metabolism·2026
Same author

Rail-BEV: A LiDAR-Centric and Sensor-Aware BEV Perception Framework for Long-Range Railway Obstacle Detection.

Sensors (Basel, Switzerland)·2026
Same author

A ventral hippocampus to nucleus accumbens pathway regulates impulsivity in male but not female rats.

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology·2026
Same author

From Satiety to Substance Use: Neural Mechanisms of GLP-1 Signaling in Appetite and Reward.

Biological psychiatry·2026
Same journal

A human-specific genetic modifier reconfigures large-scale cortical network dynamics underlying behavioral performance.

bioRxiv : the preprint server for biology·2026
Same journal

<i>Staphylococcus aureus</i> uses a eukaryotic-like uridyltransferase to make UDP-GlcNAc for cell wall synthesis.

bioRxiv : the preprint server for biology·2026
Same journal

Dynamic redistribution of eIF4F controls cap-dependent translation initiation.

bioRxiv : the preprint server for biology·2026
Same journal

When does additional information improve accuracy of RNA secondary structure prediction?

bioRxiv : the preprint server for biology·2026
Same journal

Normative brain-state trajectories reveal deviation from healthy aging in Alzheimer's disease.

bioRxiv : the preprint server for biology·2026
Same journal

Noradrenergic infraslow rhythm during sleep is the critical link between heart-rate dynamics and memory consolidation.

bioRxiv : the preprint server for biology·2026
See all related articles

Related Experiment Video

Updated: Jul 12, 2025

Author Spotlight: Investigating Neural Activity of Dentate Gyrus Granule Cells with Miniature Microscope
07:00

Author Spotlight: Investigating Neural Activity of Dentate Gyrus Granule Cells with Miniature Microscope

Published on: August 2, 2024

1.6K

Ventral hippocampus neurons encode meal-related memory.

Léa Décarie-Spain1, Cindy Gu1, Logan Tierno Lauer1

  • 1Human & Evolutionary Biology Section, Department of Biological Sciences, University of Southern California, Los Angeles, California, United States.

Biorxiv : the Preprint Server for Biology
|October 24, 2023
PubMed
Summary
This summary is machine-generated.

Scientists discovered that specific neurons in the ventral hippocampus (HPCv) activate during meals, forming memories crucial for foraging. Disrupting these meal-responsive neurons impairs spatial memory without affecting hunger.

More Related Videos

Preparation of Acute Slices from Dorsal Hippocampus for Whole-Cell Recording and Neuronal Reconstruction in the Dentate Gyrus of Adult Mice
10:45

Preparation of Acute Slices from Dorsal Hippocampus for Whole-Cell Recording and Neuronal Reconstruction in the Dentate Gyrus of Adult Mice

Published on: April 3, 2021

7.4K
Combined Mechanical and Enzymatic Dissociation of Mouse Brain Hippocampal Tissue
07:14

Combined Mechanical and Enzymatic Dissociation of Mouse Brain Hippocampal Tissue

Published on: October 21, 2021

3.9K

Related Experiment Videos

Last Updated: Jul 12, 2025

Author Spotlight: Investigating Neural Activity of Dentate Gyrus Granule Cells with Miniature Microscope
07:00

Author Spotlight: Investigating Neural Activity of Dentate Gyrus Granule Cells with Miniature Microscope

Published on: August 2, 2024

1.6K
Preparation of Acute Slices from Dorsal Hippocampus for Whole-Cell Recording and Neuronal Reconstruction in the Dentate Gyrus of Adult Mice
10:45

Preparation of Acute Slices from Dorsal Hippocampus for Whole-Cell Recording and Neuronal Reconstruction in the Dentate Gyrus of Adult Mice

Published on: April 3, 2021

7.4K
Combined Mechanical and Enzymatic Dissociation of Mouse Brain Hippocampal Tissue
07:14

Combined Mechanical and Enzymatic Dissociation of Mouse Brain Hippocampal Tissue

Published on: October 21, 2021

3.9K

Area of Science:

  • Neuroscience
  • Memory Research
  • Behavioral Biology

Background:

  • Efficient energy acquisition relies on encoding and retrieving meal-related information.
  • The neural mechanisms underlying meal memory formation are not well understood.

Purpose of the Study:

  • To identify neural populations involved in encoding meal-related information.
  • To investigate the role of these neurons in spatial memory and foraging behavior.

Main Methods:

  • Recorded neuronal activity in the ventral hippocampus (HPCv) during meal consumption.
  • Used targeted recombination-mediated ablation to study HPCv meal-responsive neurons.
  • Performed single-nucleus RNA sequencing and in situ hybridization.
  • Utilized chemogenetics to manipulate HPCv-to-lateral hypothalamic area (LHA) projections.
  • Administered intra-HPCv serotonin 2a receptor (5HT2aR) antagonists.

Main Results:

  • Ventral hippocampus (HPCv) neuronal activity increased during meals and predicted spatial memory performance.
  • Ablation of HPCv meal-responsive neurons impaired foraging-related spatial memory but not food motivation or anxiety.
  • These neurons project to the LHA and express serotonin 2a receptors (5HT2aR).
  • Silencing HPCv-LHA projections or blocking 5HT2aR in the HPCv caused memory deficits and altered eating patterns.

Conclusions:

  • Identified a specific population of ventral hippocampus (HPCv) neurons that dynamically respond to eating.
  • These HPCv neurons encode meal-related memories essential for foraging.
  • The 5HT2aR signaling pathway in HPCv neurons plays a role in regulating eating behavior and memory.