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Updated: Jul 12, 2025

Repressing Gene Transcription by Redirecting Cellular Machinery with Chemical Epigenetic Modifiers
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ASPSCR1-TFE3 reprograms transcription by organizing enhancer loops around hexameric VCP/p97.

Amir Pozner, Shiv Prakash Verma, Li Li

    Biorxiv : the Preprint Server for Biology
    |October 24, 2023
    PubMed
    Summary

    The VCP/p97 protein is essential for the ASPSCR1-TFE3 oncoprotein to drive rare cancers like alveolar soft part sarcoma (ASPS) and Xp11-rearranged renal cell carcinoma (RCC). Inhibiting VCP/p97 offers a promising new therapeutic strategy for these challenging diseases.

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