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Updated: Jul 12, 2025
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Methods to Classify Cytoplasmic Foci as Mammalian Stress Granules
Published on: May 12, 2017
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PARP10 is Critical for Stress Granule Initiation
Aravinth Kumar Jayabalan1, Krishna Bhambhani2, Anthony K L Leung1,3,4,5
1Department of Biochemistry and Molecular Biology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21205, USA.
Biorxiv : the Preprint Server for Biology
|October 24, 2023
Summary
Researchers identified Poly(ADP-ribose) polymerase 10 (PARP10) as crucial for initiating stress granule (SG) assembly. PARP10 regulates SG formation by modifying G3BP1, impacting protein recruitment and condensate dynamics.
Area of Science:
- Cell Biology
- Biochemistry
- Molecular Biology
Background:
- Stress granules (SGs) are dynamic cytoplasmic foci involved in cellular stress responses.
- Dysfunctional SGs are linked to diseases like cancer and neurodegeneration.
- The precise enzymatic trigger for SG assembly remains elusive, despite the known role of poly(ADP-ribose) (PAR).
Conclusions:
- ADP-ribosylation by PARP10 acts as a rate-limiting step in initiating stress granule formation.
- PARP10-mediated modification of G3BP1 is a key mechanism driving SG assembly.
- Targeting PARP10 could offer therapeutic strategies for SG-related diseases.
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