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Brain network hypersensitivity underlies pain crises in sickle cell disease

Pangyu Joo, Minkyung Kim, Brianna Kish

    Medrxiv : the Preprint Server for Health Sciences
    |October 24, 2023
    PubMed
    Summary

    Sickle cell disease (SCD) disrupts brain networks, leading to hypersensitivity and predictable pain crises. Explosive synchronization (ES) and frequency disassortativity (FDA) in brain activity correlate with pain and predict vaso-occlusive crises (VOCs).

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