Jove
Visualize
Contact Us

Related Experiment Videos

[Cholinergic systems in bronchospasm].

H D Brandt

    South African Medical Journal = Suid-Afrikaanse Tydskrif Vir Geneeskunde
    |December 6, 1986
    PubMed
    Summary
    This summary is machine-generated.

    The cholinergic system in airways controls breathing and patency. Bronchodilator drugs, like beta-adrenergic stimulants, target this system to relieve bronchospasm.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Decreasing asthma morbidity.

    South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde·1994
    Same author

    The dose-related hyper-and-hypokalaemic effects of salbutamol and its arrhythmogenic potential.

    British journal of pharmacology·1994
    Same author

    The assessment of mucociliary clearance using monodisperse 99mTc-tagged red blood cells.

    American journal of physiologic imaging·1991
    Same author

    Apparent racial difference in response to angiotensin I infusion.

    European journal of clinical pharmacology·1990
    Same author

    The clinical value of a drug dosage.

    South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde·1989
    Same author

    Apparent affinity values of beta-adrenergic blockers in a tissue with a mixture of beta-adrenergic receptor subtypes.

    Archives internationales de pharmacodynamie et de therapie·1987
    Same journal

    SAMA Health Summit Abstracts.

    South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde·2026
    Same journal

    On behalf of the South African Medical Association (SAMA), The Scientific Committee of the SAMA Health Summit, is pleased to pesent this abstract issue, showcasing the posters and oral presentations delivered at the Summit, which was held from 22-24 May 2026.

    South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde·2026
    Same journal

    Proceedings of the 2<sup>nd</sup> Data Driven Surgery Conference (DDSC 2025).

    South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde·2026
    Same journal

    Clinical practice guidelines for the management of fever and neutropenia in South African children and adolescents with cancer.

    South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde·2026
    Same journal

    The changing fortunes of the District Health System in SA (1994 - 2020): A retrospective review.

    South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde·2026
    Same journal

    Thomas Micheal Guntram Ignaz Rehle (1951 - 2025).

    South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde·2026
    See all related articles
    JoVE
    x logofacebook logolinkedin logoyoutube logo
    ABOUT JoVE
    OverviewLeadershipBlogJoVE Help Center
    AUTHORS
    Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
    LIBRARIANS
    TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
    RESEARCH
    JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
    EDUCATION
    JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
    Terms & Conditions of Use
    Privacy Policy
    Policies

    Area of Science:

    • Neuroscience
    • Pulmonology
    • Pharmacology

    Context:

    • The cholinergic system, both neuronal and non-neuronal, plays a critical role in regulating airway function.
    • Neuronal pathways originate in the brainstem and influence smooth muscle, ciliated, and mucus-producing cells.
    • Non-neuronal pathways involve mast cells, releasing mediators that can induce bronchospasm.

    Purpose:

    • To elucidate the mechanisms of airway patency control by the cholinergic system.
    • To review the pharmacological targets and efficacy of various bronchodilator drugs.
    • To differentiate between direct and indirect actions of cholinergic mediators on airway tone.

    Summary:

    • The neuronal cholinergic system regulates airway patency and breathing depth via efferent pathways.

    Related Experiment Videos

  • Non-neuronal cholinergic systems on mast cells contribute to bronchospasm through mediator release.
  • Effective bronchodilators include physiological antagonists (beta-adrenergic stimulants, methylxanthines) and mast cell stabilizers (sodium cromoglycate).

    • Impact:

    • Understanding cholinergic pathways is crucial for developing effective treatments for obstructive airway diseases.
    • Pharmacological interventions targeting the cholinergic system offer therapeutic benefits for managing bronchospasm.
    • This research highlights the complex interplay between neuronal, non-neuronal, and pharmacological factors in airway regulation.