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Related Concept Videos

Alzheimer's Disease: Treatment01:22

Alzheimer's Disease: Treatment

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Alzheimer's Disease (AD), a neurodegenerative disorder, is pathologically identified by amyloid plaques and neurofibrillary tangles composed of tau protein. AD pharmacotherapy aims to manage cognitive symptoms, delay disease progression, and treat behavioral symptoms. The treatment is primarily symptomatic and palliative, with no definitive disease-modifying therapy available. Cholinesterase inhibitors, including donepezil (Aricept), rivastigmine (Exelon), and galantamine (Razadyne), are...
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Alzheimer's Disease: Overview01:26

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Alzheimer's Disease (AD) is a continually advancing neurodegenerative disorder, distinguished by escalating memory loss, cognitive dysfunction, and dementia. The disease unfolds in three stages: preclinical, mild cognitive impairment (MCI), and dementia. Its onset is insidious, and the progression gradual, with the cause not well explained by other disorders.
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Parkinson's Disease: Treatment01:24

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Neurodegenerative disorders, such as Parkinson's Disease (PD), involve the gradual and irreversible destruction of neurons in particular brain areas. These disorders exhibit standard features like proteinopathies, selective vulnerability of some neurons, and an interaction of intrinsic properties, genetics, and environmental influences in neural injury.
Parkinson's Disease is primarily a result of the loss of dopaminergic neurons in the substantia nigra pars compacta. The cornerstone of...
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Parkinson's Disease: Overview01:15

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Neurodegenerative disorders are progressive diseases that cause irreversible damage and loss to neurons in specific brain areas. Examples of these disorders include Parkinson's disease, Alzheimer's disease, Multiple Sclerosis (MS), and Amyotrophic Lateral Sclerosis (ALS). These disorders share characteristics such as proteinopathies, selective neuronal vulnerability, and a complex interplay between genetic and environmental factors. The primary therapeutic goal for these conditions is...
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Related Experiment Video

Updated: Jul 12, 2025

Assessment of Spontaneous Alternation, Novel Object Recognition and Limb Clasping in Transgenic Mouse Models of Amyloid-β and Tau Neuropathology
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Multimodal Precision Prevention - A New Direction in Alzheimer's Disease.

M Barbera1, D Perera, A Matton

  • 1Miia Kivipelto, Address: Division of Clinical Geriatrics, Center for Alzheimer Research, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Karolinska Vägen 37A, 171 64 Solna, Sweden, Email: miia.kivipelto@ki.se, Phone: +46 73-994-0922.

The Journal of Prevention of Alzheimer'S Disease
|October 24, 2023
PubMed
Summary

Multimodal approaches targeting modifiable risk factors show promise for preventing cognitive decline and dementia. Combining lifestyle interventions with new therapies offers a path toward effective dementia risk reduction worldwide.

Keywords:
Alzheimer’s diseaseclinical trialsmultimodal interventionsprecision prevention

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Area of Science:

  • Neuroscience
  • Public Health
  • Gerontology

Background:

  • Dementia affects millions globally, with 40% of cases linked to modifiable risk factors.
  • Current treatments like anti-amyloid antibodies have limited eligibility.
  • Complex, multi-factorial pathologies necessitate broader therapeutic strategies beyond single targets.

Purpose of the Study:

  • To review state-of-the-art multimodal lifestyle-based approaches for cognitive impairment and dementia prevention.
  • To discuss emerging biological mechanisms and precision prevention strategies.
  • To present a novel trial design integrating lifestyle changes and pharmacological treatment within the World-Wide FINGERS network.

Main Methods:

  • Review of multimodal lifestyle intervention studies, focusing on the FINGER trial.
  • Analysis of biological mechanisms underlying cognitive decline and dementia.
  • Description of a new trial design for combination therapy (lifestyle + repurposed drug).

Main Results:

  • Multimodal interventions, exemplified by the FINGER trial, demonstrate effectiveness in risk reduction for cognitive impairment and dementia.
  • The FINGER model provides valuable lessons for global implementation.
  • Precision prevention strategies are emerging to tailor interventions.

Conclusions:

  • Multimodal strategies combining lifestyle and pharmacological interventions are crucial for addressing the growing dementia epidemic.
  • The World-Wide FINGERS network facilitates global collaboration on multimodal prevention trials.
  • Personalized, timely interventions are key for effective dementia risk reduction.