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Visualization of Microbiota in Tick Guts by Whole-mount In Situ Hybridization
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Characterization of spatial lipidomic signatures in tick-bitten guinea pig skin as a model for host-vector-pathogen
Alison J Scott1,2, Alexis A Smith3, Ron M A Heeren2
1Department of Microbial Pathogenesis, University of Maryland, Baltimore, Maryland, USA.
Msystems
|October 24, 2023
Abstract
Importance:
Here, we demonstrate the adaptability of spatial "omics" methods to identify interphylum processes regulated at the vector-host interface of ticks during a mammalian blood meal. This approach enables a better understanding of complex bipartite or tripartite molecular interactions between hosts, arthropod vectors and transmitted pathogens, and contributes toward the development of spatially aware therapeutic target discovery and description.
