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Extended-release Buprenorphine Administered at Discharge in Hospitalized Persons With Opioid Use Disorder: A Case
Elizabeth Rose Hansen1, Anna Maria South, Michelle R Lofwall
1From the Department of Surgery, University of Florida College of Medicine, Gainesville, FL (ERH); Department of Medicine, University of Kentucky College of Medicine, Lexington, KY (AMS, LCF); Departments of Behavioral Science and Psychiatry, University of Kentucky College of Medicine, Lexington, KY (MRL); Center on Drug and Alcohol Research, University of Kentucky College of Medicine, Lexington, KY (LCF, MRL); and UK Addiction Consult and Education Service (LCF).
Introduction:
Monthly subcutaneous injectable buprenorphine (XR-Bup) is an option for treatment of opioid use disorder (OUD) that addresses some sublingual buprenorphine adherence barriers and is infrequently offered to hospitalized patients with OUD.
Methods:
A retrospective case series was performed for patients receiving XR-Bup upon discharge from 1 academic medical center. Demographic information, diagnoses, follow-up, and documented factors informing the selection of XR-Bup were extracted from the electronic health record.
Results:
In 1 year, 37 hospitalized patients with OUD received XR-Bup at discharge. The average age was 37.6 years, and patients were primarily Medicaid insured with an injection-related infection. The most common documented factors informing the selection of XR-Bup were as follows: previous sublingual buprenorphine adherence barriers, concurrent stimulant use disorder, and patient preference. Sixty-four percent of patients scheduled for follow-up attended appointments, and 55% received a second dose of XR-Bup.
Conclusions:
Subcutaneous injectable buprenorphine is an option for OUD treatment among hospitalized patients providing 30 or more days of buprenorphine coverage in the postdischarge period.
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