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The good, the bald, and the hairy: A mechanosensor meets its fate at the target
Christopher D Deppmann1, Eli R Zunder2
1Department of Biology, College of Arts and Sciences, Charlottesville, VA 22902, USA; Neuroscience Graduate Program, School of Medicine, University of Virginia, Charlottesville, VA 229022, USA; Department of Biomedical Engineering, School of Engineering, University of Virginia, Charlottesville, VA 22902, USA; Department of Neuroscience, School of Medicine, University of Virginia, Charlottesville, VA 229022, USA; Department of Cell Biology, School of Medicine, University of Virginia, Charlottesville, VA 229022, USA; Program in Fundamental Neuroscience, College of Arts and Sciences, Charlottesville, VA 22902, USA.
Abstract:
In this issue of Developmental Cell, Koutsioumpa et al. (2023) investigate the maturation of low-threshold mechanoreceptor nerve endings in both hairy and glabrous skin types and discover a critical role for target-derived BMP in the development of Meissner corpuscles in glabrous (i.e., hairless) skin.
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