[Recent developments in the application of covalent organic frameworks in capillary electrochromatography]
Guo-Xiu Wang1, Yong-Lei Chen1, Wen-Juan Lü1
11. College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000, China.
Se Pu = Chinese Journal of Chromatography
|October 24, 2023
Summary
Covalent organic frameworks (COFs) are advanced materials enhancing capillary electrochromatography (CEC) separations. This review details COF stationary phase development and applications in analyzing diverse compounds, from pesticides to chiral drugs.
Area of Science:
- Analytical Chemistry
- Materials Science
Context:
- Capillary electrochromatography (CEC) merges HPLC selectivity and CE efficiency.
- Stationary phase selection is critical for CEC separation performance.
- Covalent organic frameworks (COFs) offer unique properties for advanced CEC applications.
Purpose:
- To systematically review the development and applications of COFs as stationary phases in CEC from 2016 to 2023.
- To introduce COF-based capillary columns and their preparation methods.
- To summarize the separation mechanisms and applications of COF-based CEC.
Summary:
- COFs provide high porosity, large surface area, and tunable structures for enhanced CEC.
- COF stationary phases improve separations through size exclusion and analyte-framework interactions (hydrophobic, hydrogen bonding, π-π).
- Applications include separating environmental pollutants, pesticides, aromatics, amino acids, and chiral drugs.
Impact:
- Highlights the potential of COFs to significantly advance CEC technology.
- Identifies key factors contributing to the separation capabilities of COF-based CEC.
- Proposes future research directions for optimizing COF design and application in complex sample analysis.
Keywords:
capillary electrochromatography (CEC)covalent organic frameworksreviewseparationstationary phasesMore Related Videos
10:27Preparation of Highly Porous Coordination Polymer Coatings on Macroporous Polymer Monoliths for Enhanced Enrichment of Phosphopeptides
Published on: July 14, 2015
10.1K
14:12Amplification of Escherichia coli in a Continuous-Flow-PCR Microfluidic Chip and Its Detection with a Capillary Electrophoresis System
Published on: November 21, 2023
2.1K
Related Concept Videos
01:30Capillary Electrophoresis: Applications
408
Capillary electrophoretic separations offer various modes, each with unique applications. These modes include capillary zone electrophoresis, capillary gel electrophoresis, capillary array electrophoresis, capillary isoelectric focusing, capillary isotachophoresis, micellar electrokinetic chromatography, and capillary electrochromatography.
Capillary zone electrophoresis (CZE) separates ionic components based on their electrophoretic mobility. It has been used to separate proteins, amino acids,...
Capillary zone electrophoresis (CZE) separates ionic components based on their electrophoretic mobility. It has been used to separate proteins, amino acids,...
408
01:20Capillary Electrophoresis: Instrumentation
241
Capillary electrophoresis instrumentation typically consists of several key components. A high-voltage power supply generates the electric field necessary for the separation by connecting to an anode (the positively charged electrode) and a cathode (the negatively charged electrode) located in buffer reservoirs at each end of the capillary tube. The system includes a sample vial, a fused silica capillary tube coated with polyimide for mechanical strength through which the sample components...
241
01:09Ion-Exchange Chromatography
552
Ion-exchange chromatography, or IEC, is a technique for separating ions based on their affinity for the stationary phase. The stationary phase is a cross-linked polymer resin with covalently attached ionic functional groups. The functional groups can be either positively charged (cation exchangers) or negatively charged (anion exchangers). A cation exchanger consists of a polymeric anion and active cations, while an anion exchanger is a polymeric cation with active anions. The choice of...
552
01:13Principles Of Column Chromatography
6.9K
The chromatography technique was first invented in 1901 by Michael S. Tswett, a Russian botanist, to separate plant pigments using organic solvents. Further, in 1941, Archer John Porter Martin and R. L. M. Synge modified the technique by packing silica gel into a column. A mixture of amino acids was then separated on the packed column using chloroform and water mixture as the mobile phase. This was the first report on column chromatography. At present, column chromatography is a widely used...
6.9K
01:20Electrophoresis: Overview
2.0K
Electrophoresis is a powerful analytical separation technique that relies on the differential migration of charged species when subjected to an electric field. The core strength of electrophoresis lies in its ability to separate high-molecular-weight species in complex mixtures. It has found widespread use in biochemistry, molecular biology, and analytical chemistry, allowing the separation of compounds like amino acids, nucleotides, carbohydrates, and proteins with excellent resolution.
There...
There...
2.0K
00:57High-Performance Liquid Chromatography: Instrumentation
1.9K
High-performance liquid chromatography, or HPLC, is an analytical technique that separates liquid samples under high pressures. An HPLC instrument consists of glass bottles for storing solvents called mobile phase reservoirs. HPLC-grade solvents are used to maintain high purity, and the dissolved gases are removed using a degasser, such as a vacuum pumping system or sparging with helium. The solvents are then pumped into the analytical column using a screw-driven syringe or reciprocating pumps.
1.9K