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Area of Science:

  • Neuroscience
  • Brain Connectivity
  • Systems Neuroscience

Background:

  • The relationship between brain structure and function is complex.
  • A prevailing hypothesis suggests a decoupling of structure-function relationships from unimodal to transmodal cortex.
  • Existing models may overlook crucial information in understanding this relationship.

Purpose of the Study:

  • To investigate the relationship between structural and functional brain connectivity.
  • To explore the role of frequency-specific diffusion patterns in modulating structure-function relationships.
  • To test the hypothesis of structure-function decoupling across cortical hierarchies.

Main Methods:

  • Relating structural and functional connectivity using diffusion MRI and functional MRI data.
  • Employing orthogonal eigenmodes to analyze frequency-specific diffusion patterns.
  • Examining the influence of low- and high-frequency eigenmodes on cortical interactions.

Main Results:

  • Low-frequency eigenmodes contribute minimally to functional interactions in transmodal cortex, leading to divergent structure-function relationships.
  • High-frequency eigenmodes support neuronal coactivation in transmodal areas, promoting structure-function convergence.
  • High-frequency information enhances structure-function tethering, particularly in transmodal association cortices.

Conclusions:

  • The observed structure-function decoupling may not be an intrinsic property of brain organization.
  • Multiplexed and regionally specialized spatiotemporal propagation regimes can modulate the degree of structure-function decoupling.
  • Findings offer a nuanced perspective on brain organization and connectivity across cortical regions.