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Advances in Immunomodulatory MOFs for Biomedical Applications
Binjing Zhang1, Junyu Chen1, Zhou Zhu1
1State Key Laboratory of Oral Diseases, National Center for Stomatology, National Clinical Research Center for Oral Diseases, Department of Prosthodontics, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan, 610041, China.
Metal-organic frameworks (MOFs) show promise for treating diseases by modulating the immune system. This review explores MOF synthesis, applications in cancer and inflammation, and future research directions for immunomodulatory therapies.
Area of Science:
- Biomaterials Science
- Immunology
- Nanotechnology
Background:
- The immune system's role in diseases like cancer and inflammation necessitates immunomodulation strategies.
- Immunomodulation involves balancing immune responses, either suppressing overactivity or activating underactivity.
- Metal-organic frameworks (MOFs) offer potential for immunomodulation due to their biodegradability and drug delivery capabilities.
Purpose of the Study:
- To review synthesis strategies for immunomodulatory MOFs.
- To summarize recent applications of MOFs in cancer, wound healing, inflammatory diseases, and bone tissue engineering.
- To discuss design considerations for optimizing MOF immunomodulatory properties and efficacy.
Main Methods:
- Literature review of synthesis methods for immunomodulatory MOFs.
- Analysis of current applications of MOFs in various disease models.
- Examination of design principles for enhancing MOF immunomodulatory functions.
Main Results:
- MOFs can be synthesized with tailored properties for immune modulation.
- MOFs demonstrate efficacy in preclinical models for cancer immunotherapy, wound healing, and inflammatory disease management.
- Specific design considerations can optimize MOF biodegradability, drug loading, and immune response modulation.
Conclusions:
- Immunomodulatory MOFs represent a versatile platform for therapeutic interventions across diverse diseases.
- Further research into MOF design and application is crucial for advancing immunomodulatory treatments.
- MOFs hold significant potential for developing novel strategies in regenerative medicine and cancer therapy.
