Related Experiment Video
Updated: Jul 12, 2025
13:35
Segmentation and Linear Measurement for Body Composition Analysis using Slice-O-Matic and Horos
Published on: March 21, 2021
10.5K
Prevalence And Risk Factors Of Sarcopenia In Patients With Cirrhosis: An Observational Study
Ammara Abdul Majeed1, Hafeezullah Shaikh1, Abdur Rasheed2
1National Institute of Liver and GI Diseases, Dow University Hospital, Karachi, Pakistan.
JPMA. the Journal of the Pakistan Medical Association
|October 25, 2023
Summary
Sarcopenia, a loss of muscle mass, is highly prevalent in cirrhosis patients. Advanced age and liver disease severity are key predictors, highlighting the need for early detection and intervention.
Area of Science:
- Hepatology
- Geriatrics
- Nutritional Science
Background:
- Cirrhosis, a severe liver condition, is associated with significant muscle wasting.
- Sarcopenia poses a major health risk, impacting patient outcomes and quality of life.
Purpose of the Study:
- To determine the prevalence of sarcopenia in patients with cirrhosis.
- To identify independent predictors associated with sarcopenia in this population.
Main Methods:
- An observational, cross-sectional study involving 386 cirrhotic patients (aged 18-60).
- Sarcopenia assessment based on the Asian Working Group for Sarcopenia-2019 guideline (hand grip strength, chair stand test).
- Clinical and laboratory data were collected and analyzed using SPSS 26.
Main Results:
- Sarcopenia was detected in 81.3% of the studied cirrhotic patients.
- Prevalence was higher in males (59%) and those over 45 years old (84.7%).
- Significant associations found between sarcopenia and age, chair exercise, hand grip strength, hemoglobin, albumin, and potassium levels.
Conclusions:
- Sarcopenia is highly prevalent in patients with cirrhosis.
- Increasing age, comorbidities, and liver decompensation are risk factors for sarcopenia in cirrhosis.
Related Concept Videos
01:30Coronary Artery Disease I: Introduction
17
Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...
17
01:26Diseases of the Liver and Gallbladder
585
Liver and gallbladder diseases are a significant health concern, with prominent conditions including cirrhosis, hepatitis, non-alcoholic fatty liver disease (NAFLD), and gallstones. Jaundice is a common manifestation of liver and biliary disease.
Cirrhosis is characterized by the scarring of hepatic lobules in the liver, which are replaced by fibrous tissue, affecting the liver's normal functioning. NAFLD, on the other hand, is caused by an excessive build-up of fat in the liver, not...
Cirrhosis is characterized by the scarring of hepatic lobules in the liver, which are replaced by fibrous tissue, affecting the liver's normal functioning. NAFLD, on the other hand, is caused by an excessive build-up of fat in the liver, not...
585
01:24Chronic Kidney Disease II: Clinical Manifestations
12
Chronic Kidney Disease (CKD) progressively impairs multiple body systems due to the accumulation of uremic toxins, which disrupt cellular functions across various organs.Neurologic symptomsNeurologic symptoms often arise early in CKD, as uremic toxin buildup drives changes in cognitive and motor functions. Patients frequently experience fatigue, headache, confusion, difficulty concentrating, and, in severe cases, seizures. Peripheral neuropathy commonly manifests as burning sensations in the...
12
01:28Esophageal Varices-II: Clinical Features and Management
73
Esophageal varices often manifest as gastrointestinal bleeding episodes, presenting symptoms like hematemesis (vomiting of blood), hematochezia (passing fresh blood via the rectum), and melena (black, tarry stools). Other signs can include weight loss, anorexia, abdominal discomfort, jaundice, pruritus, altered mental status, and muscle cramps.
In the initial assessment, a thorough review of the patient's medical history is vital to identify risk factors such as liver disease, alcohol...
In the initial assessment, a thorough review of the patient's medical history is vital to identify risk factors such as liver disease, alcohol...
73
01:29Bone Disorders
3.6K
Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
3.6K
01:24Nephrotic Syndrome I : Introduction
9
Nephrotic Syndrome is a chronic kidney disorder defined by clinical findings such as severe proteinuria, hypoalbuminemia, hyperlipidemia, and edema. These symptoms result from damage to the glomeruli, the kidney’s filtering units, increasing their permeability to proteins.Definition and Meaning:Proteinuria, defined as the loss of more than 3.5 grams of protein per day in adults, is a crucial feature of nephrotic syndrome. This condition is often accompanied by edema, the accumulation of...
9