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Related Concept Videos

Solvents01:12

Solvents

64.7K
A solvent is a substance, most often a liquid, that can dissolve other substances. Here, the substance being dissolved is called a solute. When a solvent and a solute combine, they form a solution - a homogenous mixture of both the solvent and the solute. Water is a universal biological solvent. Its polar structure allows it to dissolve many other polar compounds. The ability of water to dissolve is governed by a balance between water molecules binding to each other and binding to the solute.
A...
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Factors Affecting Dissolution: Drug Permeability, Stability and Stereochemistry01:20

Factors Affecting Dissolution: Drug Permeability, Stability and Stereochemistry

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Orally administered drugs primarily enter the systemic circulation via passive diffusion through the intestinal membranes. The drug's absorption is influenced by drug stability in the gastrointestinal GI tract, membrane permeability, the surface area available for absorption, luminal drug concentration, and residence time in the lumen. Drug permeability can be enhanced by adjusting the lipophilicity, polarity, or molecular size of the drug, promoting its passive transport across intestinal...
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Chemical and Solubility Equilibria02:21

Chemical and Solubility Equilibria

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The free energy change associated with dissolving a solute in a liter of solvent is called the free energy of a solution, ΔGsolution. The overall ΔGsolution is expressed as the balance of ΔGinteraction against the always-favorable free-energy of mixing, ΔGmixing. Solution formation is favorable if  ΔGsolution is less than zero, whereas it is unfavorable if ΔGsolution is greater than zero. In short, for a solution to form and complete dissolution to take place,...
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Deep Eutectic Solvents: An Eco-friendly Design for Drug Engineering.

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Researchers explored deep eutectic solvents for drug formulation. These solvents utilize hydrogen bonding for enhanced drug delivery and therapeutic applications, paving the way for advanced pharmaceutical development.

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Area of Science:

  • Materials Science
  • Chemical Engineering
  • Pharmaceutical Science

Background:

  • Deep eutectic solvents (DES) are gaining attention as novel media for various chemical applications.
  • Hydrogen bonding interactions play a crucial role in the formation and properties of DES.
  • The pharmaceutical industry seeks innovative formulation strategies for improved drug delivery and therapeutic efficacy.

Purpose of the Study:

  • To highlight the preparation and application of deep eutectic solvents.
  • To emphasize the role of hydrogen bond acceptor and donor interactions in DES formation.
  • To showcase the potential of DES in drug formulation and therapeutic applications.

Main Methods:

  • Review of literature on deep eutectic solvent preparation.
  • Analysis of hydrogen bonding mechanisms in DES.
  • Exploration of DES applications in drug formulation.

Main Results:

  • Deep eutectic solvents can be effectively prepared using hydrogen bond acceptor and donor interactions.
  • These solvents demonstrate significant potential for drug formulation.
  • DES offer promising avenues for therapeutic applications.

Conclusions:

  • Deep eutectic solvents are versatile and tunable media for pharmaceutical applications.
  • Hydrogen bonding is key to designing effective DES for drug delivery.
  • Further research into DES holds promise for advancing drug formulation and therapies.