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Synthesis and physicochemical characterization of mesoporous hydroxyapatite and its application in toothpaste
Azarmidokht Nikfallah1,2, Ali Mohammadi3,2, Mohammadsadegh Ahmadakhondi4,5
1Department of Pharmaceutics, Faculty of Pharmacy, Damghan Branch, Islamic Azad University, Damghan, Iran.
Mesoporous hydroxyapatite, a novel dental material, effectively delivers thymol for oral health. Toothpaste formulated with this material shows improved taste and odor, demonstrating its suitability for dental applications.
Area of Science:
- Biomaterials Science
- Dental Materials Science
- Nanotechnology
Background:
- Mesoporous hydroxyapatite (MHA) offers high porosity and surface area, ideal for drug delivery.
- Its biocompatibility with dental tissues makes it a promising material for oral applications.
Purpose of the Study:
- To synthesize and characterize MHA.
- To evaluate MHA as a carrier for thymol, an antibacterial agent.
- To assess MHA-based toothpaste formulations for oral health.
Main Methods:
- MHA synthesized via precipitation and characterized using XRD, FTIR, DLS, FESEM, and N2 adsorption-desorption.
- Thymol loading and release studies conducted.
- Organoleptic, pH, stability, and abrasiveness tests performed on toothpaste formulations.
Main Results:
- MHA exhibited significantly higher surface area and pore volume than hydroxyapatite.
- A significant difference in thymol release profiles was observed between MHA and hydroxyapatite formulations.
- Thymol-loaded MHA toothpaste demonstrated superior organoleptic properties and acceptable pH, stability, and abrasiveness.
Conclusions:
- Mesoporous hydroxyapatite is a suitable carrier for thymol delivery in oral applications.
- MHA-based toothpaste formulations offer enhanced organoleptic attributes and are viable for dental use.
- The study highlights MHA's potential as an abrasive material in toothpaste development.
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