Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Tumor-derived DNA drives cancer-associated anemia by promoting reticulocyte clearance.

Signal transduction and targeted therapy·2026
Same author

Association of healthy lifestyle with tooth count among adults aged 20 years and above: a cross-sectional study.

BMC oral health·2026
Same author

Alginate alleviates hyperuricemia by modulating the Pediococcus acidilactici LW1-1-butyrate-NLRP3 inflammasome axis.

International journal of biological macromolecules·2026
Same author

Risk factors associated with non-curative resection and metachronous cancer after endoscopic submucosal dissection in patients with ulcerative early gastric cancer.

European journal of medical research·2026
Same author

Exosomes and pancreatic diseases: mechanisms, applications, and challenges.

European journal of medical research·2026
Same author

The Oral Microbiota and Its Implications for Inflammatory Bowel Disease: A Literature Review.

International journal of general medicine·2025
Same journal

Retraction: Commentary: One mechanism of Sishen Pill on diarrhea with kidney Yang deficiency syndrome: influencing metabolic function by intestinal microorganisms and enzyme activity mediates the gut-kidney axis.

Frontiers in cellular and infection microbiology·2026
Same journal

The CRISPR-Cas toolkit for mosquito-borne virus surveillance: detection, tracing, and discovery.

Frontiers in cellular and infection microbiology·2026
Same journal

Distinctive reproductive tract microbial characteristics associated with infertility in women: a systematic review and meta-analysis.

Frontiers in cellular and infection microbiology·2026
Same journal

STING agonist 2'3'-cGAMP as an effective adjuvant for HPV16 peptide vaccine enhances anti-tumor immunity in TC-1 mice models.

Frontiers in cellular and infection microbiology·2026
Same journal

Development and validation of a risk prediction model for hospital mortality in adult patients with <i>Staphylococcus aureus</i> bacteremia.

Frontiers in cellular and infection microbiology·2026
Same journal

Exploratory model-based optimizing isavuconazole dosing regimens for <i>Aspergillus</i> spp. in adult patients according to serum albumin levels: a pharmacokinetic/pharmacodynamic analysis using Monte Carlo simulation.

Frontiers in cellular and infection microbiology·2026
See all related articles

Related Experiment Video

Updated: Jul 12, 2025

A Method to Assess Bacteriocin Effects on the Gut Microbiota of Mice
07:54

A Method to Assess Bacteriocin Effects on the Gut Microbiota of Mice

Published on: July 25, 2017

14.3K

Gut microbiota causally affects cholelithiasis: a two-sample Mendelian randomization study.

Xin Liu1, Xingsi Qi1, Rongshuang Han1

  • 1Department of Gastroenterology, The Affiliated Hospital of Qingdao University, Qingdao, China.

Frontiers in Cellular and Infection Microbiology
|October 25, 2023
PubMed
Summary
This summary is machine-generated.

Gut bacteria play a causal role in gallstone formation (cholelithiasis). Certain bacteria increase risk, while others offer protection, potentially through bile salt hydrolase activity.

Keywords:
Mendelian randomizationbile salt hydrolasecausal relationshipgallstonesgut microbiota

More Related Videos

Bile Duct Ligation in Mice: Induction of Inflammatory Liver Injury and Fibrosis by Obstructive Cholestasis
08:56

Bile Duct Ligation in Mice: Induction of Inflammatory Liver Injury and Fibrosis by Obstructive Cholestasis

Published on: February 10, 2015

52.4K
A Method to Define the Effects of Environmental Enrichment on Colon Microbiome Biodiversity in a Mouse Colon Tumor Model
08:14

A Method to Define the Effects of Environmental Enrichment on Colon Microbiome Biodiversity in a Mouse Colon Tumor Model

Published on: February 28, 2018

8.9K

Related Experiment Videos

Last Updated: Jul 12, 2025

A Method to Assess Bacteriocin Effects on the Gut Microbiota of Mice
07:54

A Method to Assess Bacteriocin Effects on the Gut Microbiota of Mice

Published on: July 25, 2017

14.3K
Bile Duct Ligation in Mice: Induction of Inflammatory Liver Injury and Fibrosis by Obstructive Cholestasis
08:56

Bile Duct Ligation in Mice: Induction of Inflammatory Liver Injury and Fibrosis by Obstructive Cholestasis

Published on: February 10, 2015

52.4K
A Method to Define the Effects of Environmental Enrichment on Colon Microbiome Biodiversity in a Mouse Colon Tumor Model
08:14

A Method to Define the Effects of Environmental Enrichment on Colon Microbiome Biodiversity in a Mouse Colon Tumor Model

Published on: February 28, 2018

8.9K

Area of Science:

  • Gastroenterology
  • Microbiome Research
  • Genetics

Background:

  • The gut microbiota is implicated in metabolic diseases.
  • A causal link between gut microbiota and cholelithiasis (gallstones) is not well-established.

Purpose of the Study:

  • To investigate the causal relationship between gut microbiota composition and cholelithiasis.
  • To test the hypothesis that gut microbiota influences gallstone development.

Main Methods:

  • Employed a two-sample Mendelian randomization approach.
  • Utilized summary statistics from large-scale consortia (MiBioGen for microbiota, FinnGen for cholelithiasis).
  • Integrated STRING analysis for pathway exploration.

Main Results:

  • Specific bacteria like *Clostridium senegalense*, *Coprococcus3*, and *Lentisphaerae* were associated with increased cholelithiasis risk.
  • These risk-associated bacteria showed higher expression of bile salt hydrolases.
  • *Holdemania*, *Lachnospiraceae UCG010*, and *Ruminococcaceae NK4A214* were linked to a protective effect, with lower bile salt hydrolase expression.

Conclusions:

  • Gut microbiota causally influences cholelithiasis development.
  • Bile salt hydrolase activity in gut bacteria may mediate this causal link.
  • Findings offer insights for novel gallstone treatment strategies targeting the gut microbiome.