Leveraging cell-cell similarity for high-performance spatial and temporal cellular mappings from gene expression data

Single-cell trajectory mapping and spatial reconstruction are two important developments in life science and provide a unique means to decode heterogeneous tissue formation, cellular dynamics, and tissue developmental processes. The success of these techniques depends critically on the performance of analytical tools used for high-dimensional (HD) gene expression data processing. Existing methods discern the patterns of the data without explicitly considering the underlying biological characteristics of the system, often leading to suboptimal solutions. Here, we present a cell-cell similarity-driven framework of genomic data analysis for high-fidelity spatial and temporal cellular mappings. The approach exploits the similarity features of the cells to discover discriminative patterns of the data. We show that for a wide variety of datasets, the proposed approach drastically improves the accuracies of spatial and temporal mapping analyses compared with state-of-the-art techniques.