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Related Experiment Video

Updated: Jul 12, 2025

An Ex Vivo Choroid Sprouting Assay of Ocular Microvascular Angiogenesis
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Longitudinal Choroidal Development in Preterm Infants.

Suzanne M Michalak1,2, Shwetha Mangalesh1, Yineng Chen3

  • 1Department of Ophthalmology, Duke University School of Medicine, Durham, North Carolina.

Ophthalmology Science
|October 25, 2023
PubMed
Summary

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Very Preterm Infant Retinal Microanatomy at 36 Weeks' Postmenstrual Age and 2-Year Neurodevelopment.

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Utility of handheld optical coherence tomography imaging in the surgical management of preterm infants with advanced retinopathy of prematurity.

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Comparison of Retinal and Choroidal OCT Measures and Features at Term Equivalent Age in Preterm and Term Infants.

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This summary is machine-generated.

Subfoveal choroidal thickness in preterm infants grows rapidly until 38 weeks postmenstrual age (PMA), then growth nearly stops. Extremes in birth weight and prematurity significantly impact this crucial ocular development.

Area of Science:

  • Ophthalmology
  • Neonatology
  • Developmental Biology

Background:

  • Preterm infants are at increased risk for ocular abnormalities.
  • Choroidal development is critical for retinal health and visual function.
  • Understanding normative choroidal growth in preterm infants is essential for identifying potential complications.

Purpose of the Study:

  • To characterize the changes in subfoveal choroidal thickness in preterm infants.
  • To establish normative values for choroidal thickness from 30 to 60 weeks' postmenstrual age (PMA).
  • To analyze the rate of choroidal growth during this period.

Main Methods:

  • A prospective, observational study (BabySTEPS) enrolled preterm infants.
  • Handheld optical coherence tomography (OCT) was used for imaging.
Keywords:
ChoroidOptical coherencePremature infantTomography

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  • Custom software measured subfoveal choroidal thickness, with manual correction.

    • Main Results:

    • Choroidal growth followed a biphasic model: linear growth from 30 to 38.4 weeks PMA (14.8 μm/week), followed by near cessation.
    • Mean choroidal thickness at 30 weeks PMA was 141.4 μm, increasing to 306.2 μm by 56-60 weeks PMA.
    • Infants with extremely low birth weight and extremely preterm infants showed significantly slower initial growth rates.

    Conclusions:

    • Preterm infant choroidal thickness exhibits rapid linear growth until approximately 38 weeks PMA, after which growth significantly slows.
    • These findings provide foundational data on choroidal development in preterm infants.
    • Understanding the impact of prematurity and low birth weight on choroidal development is vital for assessing ocular and retinal health.