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Pembrolizumab-Induced Broken Heart Syndrome, Pneumonitis, and Hypophysitis Occurring Concurrently; A Deadly Triad

Wahab J Khan1, Muhammad Asif1, Hammad S Chaudhry1

  • 1University of South Dakota Sanford School of Medicine, Sioux Falls, SD, USA.

Journal of Community Hospital Internal Medicine Perspectives
|October 25, 2023
PubMed

Insights

Immune checkpoint inhibitors can cause rare, severe side effects affecting multiple organs. This case highlights a patient experiencing Takotsubo cardiomyopathy, hypophysitis, and pneumonitis after pembrolizumab treatment for lung cancer.

Area of Science:

  • Oncology
  • Immunology
  • Cardiology
  • Endocrinology
  • Pulmonology

Background:

  • Immune checkpoint inhibitors (ICIs) are revolutionary cancer therapies that enhance the immune system's anti-tumor response.
  • The increasing application of ICIs has led to a rise in reported immune-mediated adverse events affecting various organs.
  • Early identification of these side effects is crucial for the safe administration of ICIs.
Keywords:
HypophysitisImmune checkpoint inhibitorsPembrolizumabPneumonitisTakotsubo cardiomyopathy

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