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[Virus hijacking ESCRT system to promote self-replication: a review].

Jun Dai1,2, Xusheng Qiu2, Chan Ding2

  • 1Laboratory Animal Center, Zunyi Medical University, Zunyi 563099, Guizhou, China.

Sheng Wu Gong Cheng Xue Bao = Chinese Journal of Biotechnology
|October 25, 2023
PubMed
Summary

The Endosomal Sorting Complex Required for Transport (ESCRT) system is crucial for cell functions and viral replication. Targeting viral "late domain" motifs and ESCRT proteins offers promising antiviral therapy strategies.

Keywords:
endosomal sorting complex required for transport (ESCRT) systemhijackingreplicationvirus

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Area of Science:

  • Cell Biology
  • Virology
  • Biochemistry

Background:

  • The Endosomal Sorting Complex Required for Transport (ESCRT) machinery governs fundamental cellular processes, including vesicle trafficking and membrane dynamics.
  • Viruses exploit the ESCRT system for their replication, utilizing its components for various stages of their life cycle.
  • Viral proteins often contain
  • late domain
  • motifs that interact with host ESCRT proteins.

Approach:

  • This review synthesizes current research on the ESCRT system's composition and functions.
  • It examines the interplay between ESCRT subunits, viral
  • late domain
  • motifs, and viral replication dynamics.
  • The review also explores the antiviral potential of targeting these interactions.

Key Points:

  • The ESCRT system is essential for numerous cellular processes, making it a target for viral manipulation.
  • Viral
  • late domain
  • motifs are critical for recruiting host ESCRT proteins to facilitate viral proliferation.
  • Interference with ESCRT-mediated viral processes presents a viable therapeutic avenue.

Conclusions:

  • Understanding the ESCRT system's role in viral replication is key to developing novel antiviral therapies.
  • Targeting the interactions between viral
  • late domain
  • motifs and ESCRT proteins holds significant therapeutic promise.
  • This review provides a foundation for future drug development against viral infections.