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Related Concept Videos

Modified-Release Drug Delivery Systems: Rate-Programmed II01:19

Modified-Release Drug Delivery Systems: Rate-Programmed II

Rate-programmed drug delivery systems release drugs in a controlled manner to maintain therapeutic levels. Three main designs include reservoir, matrix, and hybrid systems.Reservoir systems consist of a drug core enclosed within a membrane that controls drug release. In non-swelling reservoir systems, polymers like ethyl cellulose or polymethacrylates are used. These do not hydrate in aqueous media and control release through membrane thickness, porosity, or insolubility. This type includes...
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Stimuli-activated drug delivery systems are designed to release drugs in response to specific physical, chemical, or biological stimuli. These systems often utilize hydrogels—three-dimensional, hydrophilic polymer networks capable of swelling in aqueous environments and retaining significant fluid volumes. Upon exposure to particular stimuli, these hydrogels undergo structural transitions that allow the embedded drug to be released. Due to this adaptive behavior, such systems are also called...

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Updated: Jun 24, 2026

An Injectable and Drug-loaded Supramolecular Hydrogel for Local Catheter Injection into the Pig Heart
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Electrochemically Controlled Release from a Thin Hydrogel Layer.

Paulina Gwardys1, Kamil Marcisz1, Damian Jagleniec1

  • 1Faculty of Chemistry, University of Warsaw, 1 Pasteura, WarsawPL 02-093, Poland.

ACS Applied Materials & Interfaces
|October 25, 2023
PubMed
Summary

Researchers developed a novel thermoresponsive hydrogel for controlled drug release. This system uses electrochemical signals to trigger the release of a model drug, showing promise for transdermal and implantable delivery systems.

Keywords:
N-isopropylacrylamideelectrochemically controlled releasing systeminclusion complexthermosensitive thin hydrogel layerβ-cyclodextrins

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Area of Science:

  • Materials Science
  • Electrochemistry
  • Biomedical Engineering

Background:

  • Development of advanced drug delivery systems is crucial for targeted and efficient therapeutic interventions.
  • Electrochemically responsive materials offer precise control over drug release kinetics.
  • Thermoresponsive hydrogels provide tunable release profiles based on temperature changes.

Purpose of the Study:

  • To present a novel electrochemically controlled release system utilizing a thermoresponsive hydrogel.
  • To functionalize poly(N-isopropylacrylamide) hydrogels with beta-cyclodextrin for drug complexation.
  • To investigate the electrochemical triggering of drug release from the functionalized hydrogel.

Main Methods:

  • Synthesis of poly(N-isopropylacrylamide)-beta-cyclodextrin (p(NIPA-βCD)) hydrogel via electrochemically induced free radical polymerization on a gold electrode.
  • Characterization of hydrogel properties using quartz crystal microbalance with dissipation monitoring (QCM-D) and scanning electron microscopy (SEM).
  • Loading of ferrocene-modified rhodamine B (RdFc) via host-guest complexation and monitoring of electrochemical release using cyclic voltammetry and spectrofluorimetry.

Main Results:

  • Successful synthesis and attachment of p(NIPA-βCD) hydrogel layer to QCM electrode.
  • Demonstrated accumulation of RdFc within the hydrogel through host-guest interactions.
  • Oxidation of ferrocene moieties effectively triggered the release of RdFc, with release controllable by applied electrode potential.

Conclusions:

  • The developed p(NIPA-βCD) hydrogel system enables precise electrochemical control over drug release.
  • The system operates effectively at near-body temperature, making it suitable for physiological applications.
  • This electrochemically triggered release system shows significant potential for transdermal drug delivery and intrabody implants.