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Periodontitis and NAFLD-related diseases: A bidirectional two-sample Mendelian randomization study
Feng Qiao1, Xiaoyan Li2, Yuchang Liu2
1Department of Oral and Maxillofacial Surgery, School and Hospital of Stomatology, Tianjin Medical University, Tianjin, China.
Oral Diseases
|October 25, 2023
Summary
This study suggests nonalcoholic fatty liver disease (NAFLD) may causally impact periodontitis. Further research is needed to explore if periodontitis affects NAFLD-related conditions.
Area of Science:
- Hepatology
- Periodontology
- Genetic Epidemiology
Background:
- Observational studies link periodontitis and nonalcoholic fatty liver disease (NAFLD).
- A definitive causal relationship between periodontitis and NAFLD remains undetermined.
- Genetic predisposition may elucidate causal links between these conditions.
Purpose of the Study:
- To investigate the bidirectional causal relationship between periodontitis and NAFLD-related diseases.
- To utilize Mendelian randomization (MR) analysis for assessing genetic causal inference.
Main Methods:
- A bidirectional two-sample Mendelian randomization (MR) analysis was performed.
- Genome-wide association study (GWAS) summary statistics for NAFLD, NASH, fibrosis, cirrhosis, and periodontitis were utilized.
- Inverse variance weighted (IVW) method and sensitivity analyses were employed to assess causality and rule out pleiotropy.
Main Results:
- Evidence suggests a potential causal link from NAFLD to periodontitis (OR, 1.094; P=0.036).
- A causal association was also observed between cirrhosis and periodontitis (OR, 1.138; P=0.048).
- No significant causal effect of periodontitis on NAFLD-related diseases was detected.
Conclusions:
- Nonalcoholic fatty liver disease (NAFLD) may have a moderate causal influence on periodontitis.
- The potential causal impact of periodontitis on NAFLD-related conditions requires additional investigation.
