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Published on: April 18, 2019
Ceftazidime/Avibactam Resistance in Carbapenemase-Producing Klebsiella pneumoniae
Abstract:
We identified a novel ceftazidime/avibactam resistance mechanism in sequence type 11 Klebsiella pneumoniae carbapenemase 2-producing K. pneumoniae. Plasmid recombination and chromosomal integration formed a novel virulence plasmid and provided an additional promoter for blaSHV-12, leading to blaSHV-12 overexpression and ceftazidime/avibactam resistance. Genetic rearrangement contributed to convergence of hypervirulence and ceftazidime/avibactam resistance.
Insights
A new mechanism for ceftazidime/avibactam resistance in Klebsiella pneumoniae was discovered. Genetic changes caused both increased virulence and drug resistance in this common pathogen.
Area of Science:
- Microbiology
- Genetics
- Molecular Biology
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